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Copy numbers count for autism

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Presentation on theme: "Copy numbers count for autism"— Presentation transcript:

1 Copy numbers count for autism
Michael Gross  Current Biology  Volume 21, Issue 15, Pages R571-R573 (August 2011) DOI: /j.cub Copyright © Terms and Conditions

2 Mind image: Autism is characterized by a triad of impairments to social behaviour, communication and imagination. One school of thought claims that individuals with autism lack a ‘theory of mind’, implying that they don't have a concept of themselves and other people as distinct, thinking personalities with their own beliefs, desires, etc. (Photo: N.H. Gross.) Current Biology  , R571-R573DOI: ( /j.cub ) Copyright © Terms and Conditions

3 Labelled autistic: Temple Grandin, one of the first generation of children to be diagnosed with autism, managed to build a successful career in animal science partly by using her own unusual sensitivity and anxieties to better understand animals. She is the author of a widely known memoir (Emergence: Labeled Autistic) and the subject of a recent HBO film in which the actor Claire Danes impersonates her. (Photo: Jonathan D. Thoreson.) Current Biology  , R571-R573DOI: ( /j.cub ) Copyright © Terms and Conditions

4 Counting copies: Large sections of DNA, which may contain one or several genes, are often found duplicated in the human genome. These so called copy number variations are as important for human genetic diversity as point mutations and have recently been implicated in medical conditions including autism. (Photo: M. Gross.) Current Biology  , R571-R573DOI: ( /j.cub ) Copyright © Terms and Conditions


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