1. How to Achieve Aggressive BP Goals in Difficult-to-Treat Patients

3. Program Overview

4. Disease and Injury Attributable to Major CV Risk Factors: Worldwide in 2010

5. BP Reduction and CV Complications

6. Difficult-to-Treat HTN

7. BP Goals in Patients With HTN

8. Barriers to Achieving BP Control in Patients With HTN

9. Measures of Patient Adherence

10. Strategies for Physicians to Address Medication Adherence in HTN

11. Case Study: 58-Year-Old Man With HTN

12. 58-Year-Old Man With HTN: Examination and Laboratory Measurements

13. 58-Year-Old Man With HTN: Sonograph of the Kidneys

14. 58-Year-Old Man With HTN: Electrocardiogram at Rest

15. Clinical Question 1

16. Treatment Option: Add Ramipril 10 mg Once Daily

17. Treatment Option: Increase Dose of HCTZ To 25 mg Once Daily

18. ABPM

19. Treatment Option: Add Carvedilol 25 mg Twice Daily

20. Treatment Option: Add Amlodipine 5 mg Once Daily

21. Combination Therapy Increases BP-Lowering Much More Effectively Than Monotherapy

22. Treatment Alternative

23. Combination Antihypertensive Therapy for Patients With Difficult-to-Treat HTN

24. 58-Year-Old Man With HTN: Treatment Plan

25. FDC Agents Have Been Shown to Improve Adherence

26. Advantages and Disadvantages of FDC Agents for the Treatment of HTN

27. Use of FDC Agents in Patients With HTN and HF

28. Thiazides vs Loop Diuretics in Patients With HTN

29. Summary and Conclusions

30. Summary and Conclusions (cont)

31. Abbreviations

32. Abbreviations (cont)

33. Abbreviations (cont)