1. Module 8
Muscular System

2. Lecture outline Structure of a skeletal muscle
Connective tissue covering
Skeletal muscle fiber
Neuromuscular Junction
Motor Units
Skeletal muscle contraction
Role of Myosin and Actin
Stimulus for Contraction
Skeletal Anatomy

3. Module 8.1
Objective- Read 8.1 and be able to describe the various functions of the muscle system. Be able to list and describe the microscopic structure of each type of muscle tissue and where it might be found in the body.
Also list which muscle type is voluntary, or involuntary.

4. Function of the Muscle System
Provides motor movement.
Maintain posture and body position
Support soft tissue- abdominal wall
Helps Maintain body temperature
Propel body fluids and food, and generates heart beat.

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Introduction:
A. All movements require muscle which are organs using chemical energy to contract.
B. The three types of muscle in the body are skeletal, smooth, and cardiac muscle.

7. The Skeletal muscle
This lecture emphasizes skeletal muscle contraction – smooth and cardiac muscle contraction follow similar processes during contraction!

8. Module 8.2
Objective- Read 8.2 and describe how connective tissue is part of skeletal muscle- the layers of connective tissue.
Be able to describe the microanatomy of the skeletal muscle fiber (cell) and the function of each structure.
Be able to define motor neuron and describe a neuromuscular junction and process of neuron impulse and initiation of a muscle contraction.

9. Structure of a Skeletal Muscle
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Structure of a Skeletal Muscle
A. Each muscle is an organ, comprised of skeletal muscle tissue, connective tissues, nervous tissue, and blood.
B. Each cell in skeletal muscle tissue is a single muscle fiber

10. Three Layers of connective tissue come together and become the tendon Epi=on, Peri= around, Endo=inside

11. Muscle cell = muscle cell striations
Three Layers come together and become the tendon Epi=on, Peri= around, Endo=inside

12. B. Connective Tissue Coverings
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B. Connective Tissue Coverings
1. Layers of dense connective tissue, called fascia, surround the epimysium and separate each muscle.
2. This connective tissue extends beyond the ends of the muscle and gives rise to tendons that are fused to the periosteum of bones.

13. C. Skeletal Muscle Fibers
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C. Skeletal Muscle Fibers
1. Each muscle fiber is a single, long, cylindrical muscle cell.
2. Beneath the sarcolemma (cell membrane) lies sarcoplasm (cytoplasm) with many mitochondria and nuclei; the sarcoplasm contains many myofibrils.
Do now- What element do you think regulates contraction?
Hint the skin produces vitamin D to allow absorption to occur in the digestive tract.

14. Sarcolemma-cell membrane
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Sarcoplasmic Reticulum- stores calcium
Muscle Cell
Sarcolemma-cell membrane

15. Filaments of the MyoFibril
a. Thick filaments of myofibrils are made up of the protein myosin.
b. Thin filaments of myofibrils are made up of the protein actin.
c. The organization of these filaments produces striations.

16. Sacromere- Actin Myosin Functional unit of muscle
Sarcoplasmic reticulum
Sarcolemma
Actin
Myosin
Sacromere-
Functional unit of muscle

17. 3. A sarcomere extends from Z line to Z line.
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3. A sarcomere extends from Z line to Z line.
a. I bands (light bands) made up of actin filaments are anchored to Z lines.
b. A bands (dark bands) are made up of thick filaments and the overlapping thick and thin filaments.

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4. Beneath the sarcolemma of a muscle fiber lies the sarcoplasmic reticulum (endoplasmic reticulum), which store the inorganic mineral calcium that initiates contraction.
The sarcoplasmic reticulum is associated with transverse (T) tubules (invaginations of the sarcolemma- the cell membrane). Thus, the cell membrane travels deep within the cell to signal the release of calcium to initiate contraction.

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Transverse tubule

20. D. Neuromuscular Junction
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D. Neuromuscular Junction
1. The site where the motor neuron and muscle fiber meet is the neuromuscular junction.
a. The muscle fiber membrane forms a motor end plate in which the sarcolemma is tightly folded and where nuclei and mitochondria are abundant.
b. The cytoplasm of the motor neuron contains numerous mitochondria and synaptic vesicles storing neurotransmitters.

21. Recall that there are Two major types of neurons
Sensory –
Sends information to the brain
Motor -
Sends information to muscle or glands

22. Sarcolemma Repeating Sacromeres
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Sarcolemma
Repeating Sacromeres

23. Signals contraction
Neurotransmitter
Acetylcholine

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E. Motor Units
1. A motor neuron and the muscle fibers it controls make up a motor unit; when stimulated to do so, the muscle fibers of the motor unit contract all at once.

25. Module 8.3
Objective- Read 8.3 and be able to explain the major events of skeletal muscle fiber contraction- the “Sliding Filament Theory”
Be able to explain how the fiber contraction obtain energy

26.  Skeletal Muscle Contraction
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 Skeletal Muscle Contraction
A. Muscle contraction involves several components that result in the shortening of sarcomeres, and the pulling of the muscle against its attachments.

27. Sacromere Myosin Actin
Once the signal reaches the muscle cellCalcium is released from the sarcoplasmic Reticum and exposes active site
Contractile proteins- Actin and Myosin
Regulatory proteins- Troponin and tropomyosin

28. This process is also known as the “sliding filament theory”
Actin
Myosin
This process is also known as the “sliding filament theory”

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D. Energy Sources for Contraction 1. Energy for contraction comes from molecules of ATP. This chemical is in limited supply and so must often be regenerated
2. Creatine phosphate, which stores excess energy released by the mitochondria, is present to regenerate ATP from ADP and phosphate.

34. Module 8.5
Objective- Read 8.5 and distinguish between the structures and functions of a multiunit smooth muscle and visceral smooth muscle.
Compare the neurotransmitters that affect smooth muscle and skeletal muscle.

35.  Smooth Muscles A. Smooth Muscle Fibers
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 Smooth Muscles
A. Smooth Muscle Fibers
1. Smooth muscle cells are elongated with tapered ends, lack striations, and have a relatively undeveloped sarcoplasmic reticulum.

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2. Multiunit smooth muscle and visceral muscle are two types of smooth muscles.
a. In multiunit smooth muscle, such as in the blood vessels and iris of the eye, fibers occur separately rather than as sheets.

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b. Visceral smooth muscle occurs in sheets and is found in the walls of hollow organs; these fibers can stimulate one another and display rhythmicity, and are thus responsible for peristalsis in hollow organs and tubes.

39. B. Smooth Muscle Contraction
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B. Smooth Muscle Contraction
1. The myosin-binding-to-actin mechanism is the mostly same for smooth muscles and skeletal muscles.
2. Both acetylcholine and norepinephrine stimulate and inhibit smooth muscle contraction, depending on the target muscle.

40. 3. Hormones can also stimulate or inhibit contraction.
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3. Hormones can also stimulate or inhibit contraction.
4. Smooth muscle is slower to contract and relax than is skeletal muscle, but can contract longer using the same amount of ATP.

41. Module 8.6
Objective- Read 8.6 and describe the structure of cardiac muscle cells and compare to skeletal and smooth. Compare the contraction mechanisms of skeletal and smooth muscle to cardiac.
Compare the neurotransmitters of cardiac muscle to skeletal and smooth.

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Cardiac Muscle
A. The mechanism of contraction in cardiac muscle is essentially the same as that for skeletal and smooth muscle, but with some differences.
B. Cardiac muscle has transverse tubules that supply extra calcium, and can thus contract for longer periods.

43. Intercalated discs

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C. Complex membrane junctions, called intercalated disks, join cells and transmit the force of contraction from one cell to the next, as well as aid in the rapid transmission of impulses throughout the heart.
D. Cardiac muscle is self-exciting and rhythmic, and the whole structure contracts as a unit.

45.  Skeletal Muscle Actions A. Origin and Insertion
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 Skeletal Muscle Actions
A. Origin and Insertion
1. The immovable end of a muscle is the origin, while the movable end is the insertion; contraction pulls the insertion toward the origin.
2. Some muscles have more than one insertion or origin.

46. B. Interaction of Skeletal Muscles
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B. Interaction of Skeletal Muscles
1. Of a group of muscles, the one doing the majority of the work is the prime mover.
2. Helper muscles are called synergists; opposing muscles are called antagonists.

47. Module 8.8
Objective- Read 8.8 and describe the locations and actions of the major skeletal muscles of each body region-
Note: most of this will be covered in the lab practicum so just be able to identify major skeletal muscles of each body region

48.  Major Skeletal Muscles
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 Major Skeletal Muscles
A. Muscles are named according to an of the following criteria: size, shape, location, action, number of attachments, or direction of its fibers.

51. B. Muscles of Facial Expression
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B. Muscles of Facial Expression
1. Muscles of facial expression attach to underlying bones and overlying connective tissue of skin, and are responsible for the variety of facial expressions possible in the human face.
2. Major muscles include
epicranius, orbicularis oculi,
orbicularis oris, buccinator,
zygomatigus,

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53. C. Muscles of Mastication
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C. Muscles of Mastication
1. Chewing movements include up and down as well as side-to-side grinding motions of muscles attached to the skull and lower jaw.
2. Chewing muscles include
masseter and temporalis.

57. E. Muscles that Move the Pectoral Girdle
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E. Muscles that Move the Pectoral Girdle
1. The chest and shoulder muscles move the scapula.
2. Major muscles include trapezius, rhomboideus major,levator scapulae,
serratus anterior, and pectoralis
minor.

61. F. Muscles that Move the Arm
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F. Muscles that Move the Arm
1. Muscles connect the arm to the pectoral girdle, ribs, and vertebral column, making the arm freely movable.
2. Flexors include the coracobrachialis and pectoralis major.

64. 3. Extensors include the teres major
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3. Extensors include the teres major
and latissimus dorsi.
4. Abductors include the
supraspinatus and the deltoid.
5. Rotators are the subscapularis,
infraspinatus, and teres minor.

65. 2. Flexors are the biceps brachii, brachialis,and brachioradialis.
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G. Muscles that Move the Forearm 1. These muscles arise from the humerus or pectoral girdle and connect to the ulna and radius.
2. Flexors are the biceps brachii,
brachialis,and brachioradialis.

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67. 3. An extensor is the triceps brachii muscle.
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3. An extensor is the triceps brachii muscle.
4. Rotators include the supinator, pronator teres, and pronator quadratus.

69. H. Muscles that Move the Wrist, Hand, and Fingers
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H. Muscles that Move the Wrist, Hand, and Fingers
1. Movements of the hand are caused by muscles originating from the distal humerus, and the radius and ulna.
2. Flexors include the flexor carpi radialis, flexor carpi ulnaris, palmaris longus, and flexor digitorum profundus.

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3. Extensors include the extensor carpi radialis longus, extensor carpi radialis brevis, extensor carpi ulnaris, and extensor digitorum.

71. I. Muscles of the Abdominal Wall
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I. Muscles of the Abdominal Wall
1. This group of muscles connects the rib cage and vertebral column to the pelvic girdle.
a. A band of tough connective tissue, the linea alba, extending from the xiphoid process to the symphysis pubis, serves as an attachment for certain abdominal wall muscles.

72. 2. These four muscles include:
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2. These four muscles include:
external oblique, internal oblique, transverse abdominis, and rectus abdominis.

73. K. Muscles that Move the Thigh
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K. Muscles that Move the Thigh
1. The muscles that move the thigh are attached to the femur and to the pelvic girdle.
2. Anterior group includes the psoas major and iliacus.

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3. Posterior group is made up of the gluteus maximus, gluteus medius, gluteus minimus, and tensor fasciae latae.
4. Thigh adductors include the adductor longus, adductor magnus, and gracilis.

76. L. Muscles that Move the Leg
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L. Muscles that Move the Leg
1. This group connects the tibia or fibula to the femur or pelvic girdle.
2. Flexors are the biceps femoris, semitendinosus, semimembranosus,
and sartorius.
3. An extensor is the quadruceps femoris
group made up of four parts: rectus femoris, vastus lateralis, vastus medialis, and vastus intermedius.

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78. M.Muscles that Move the Ankle, Foot, and Toes
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M.Muscles that Move the Ankle, Foot, and Toes
1. Muscles that move the foot are attached to the femur, fibula, or tibia, and move the foot upward, downward, or in a turning motion.
2. Dorsal flexors include the tibialis
anterior, peroneus tertius, and extensor digitorum longus.

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3. Plantar flexors are the gastrocnemius soleus, and flexor digitorum longus.