1. Dr. Christopher Hentschel
Ulysses Advisory Group
Best Practices: Entrepreneurial Ecosystems around the World

2. Public-Private Ecosystems Optimize Healthcare R&D
Ulysses Advisory Group
Public-Private Ecosystems Optimize Healthcare R&D
Image here. Always this height, but width can vary
Basic Research Translational Research Product Development

3. 3

4. Public-Private Ecosystems Optimize Healthcare R&D
Ulysses Advisory Group
Public-Private Ecosystems Optimize Healthcare R&D
Image here. Always this height, but width can vary
Neither the public nor the
private sectors alone can
Deliver optimal healthcare
R&D.
But together there is the
potential for enormous
synergy and progress.
Basic Research Translational Research Product Development
Examples 1: MRC , London UK;
Example 2: MMV, Geneva (backup)

5. Universities >>>> PPPs >>>>>> Industry
Ulysses Advisory Group
Public-Private Partnerships Optimize R&D productivity, particularly where incentives are needed for the private sector to engage
Public Goods Common Goods Private Goods
Universities >>>> PPPs >>>>>> Industry
PPPs help mitigate the ‘Valley of Death’ Phenomenon

6. MRC discoveries and developments
Ulysses Advisory Group
MRC discoveries and developments
Rickets caused by lack of vitamin D (1916)
Discovery and development of penicillin (1940s)
Pioneered randomised controlled trial design (1940s)
Structure of DNA (1950s)
Discovery of link between smoking and cancer (1950s)
Clinical trials for radiotherapy for cancer (1960s)
Chemotherapy for leukaemia and monoclonal antibodies (1970s)
Invention of DNA fingerprinting (1980s)
Gene for Huntington’s disease discovered (1990s)
Humanised therapeutic antibodies in widespread use (2000s)
22 Nobel prizes have been awarded to MRC-supported scientists
MRC Collaborative Centre (1987) > MRCT + MVM (2000 – Present) 6

7. NIMR 1913 – 2013 → Francis Crick Institute (2016)
Ulysses Advisory Group
NIMR 1913 – 2013 → Francis Crick Institute (2016) 7

8. Translation of basic research takes time
Ulysses Advisory Group
Translation of basic research takes time
1973: Mouse monoclonal antibodies isolated by César Milstein
1986: Michael Neuberger and Greg Winter ‘humanise’ mouse antibodies and develops and the technology for producing antibodies in vitro
2003: MRC-developed Humira® licensed to treat arthritis
2008: 21 monoclonal antibody drugs on market for treating breast cancer, leukaemia, asthma, arthritis, psoriasis and transplant rejection
2011: Antibodies make up 1/3 of new drugs for cancer, arthritis and asthma; global antibody market estimated to be worth $50bn
2016: Bio-similars market developing in emerging economies

9. MRC exploitation results since 1987
Ulysses Advisory Group
MRC exploitation results since 1987
92 new products and interventions launched, including several ‘blockbusters’.
Creation of 104 companies, 56 formed since 2006.
578 patents granted since 2006, with around 30% licensed with royalty income >$250m since 2006
More than 100 new industry collaborations are reported every year
Lead partner in the new European Innovative Medicines Initiative

10. the biggest PPP in Life Science
EU Innovative Medicines Initiative:
Ulysses Advisory Group
The European Union and the pharmaceutical industry
have joined forces to make
drug R&D processes in Europe more innovative and efficient,
enhance Europe’s competitiveness
& address key societal challenges
by forming
the biggest PPP in Life Science 10

11. Ulysses Advisory Group

12. Thank You For Your Attention
Ulysses Advisory Group
Thank You For Your Attention
For more information see ulyssesadvisorygroup.com
Confidential 12

14. Backup Slides: MMV Geneva
Ulysses Advisory Group
Backup Slides: MMV Geneva
For more information see ulyssesadvisorygroup.com
Confidential 14

15. Ulysses Advisory Group
MMV’s mission
“Medicines for Malaria Venture is a not-for-profit foundation dedicated to reducing the burden of malaria in disease endemic countries by
discovering, developing and delivering
new affordable antimalarials through effective
public-private partnerships.”

16. MMV’s global network of R&D

17. Ulysses Advisory Group
Example: MMV’s Synthetic Peroxide Project - an example of International Partnership
+ Outsourced Support
Cideim
School
Quintiles
Pharmalytics
Inveresk
Unimark
RCC
Fulcrum
Basilea
Cerb
Cerep
Maccine
MDS
ICGEB
Project team:
University of Nebraska
Swiss Tropical Institute
Monash University
Roche/Basilea
Ranbaxy Laboratories

18. Inputs and Outputs of Joint R&D
Ulysses Advisory Group
Public
MMV Input
$$$
Drug Profile
Background IPR
Link to WHO/Policy
Malaria Expertise
MMV Gets
Rights in DEC
IPR in ‘Field’
Drug Supply
Return on non DEC Sales
Joint
R&D
Pharma/Bio Gets
Rights in non DEC
IPR outside ‘Field’
PR Benefit
HR Benefit
Validation of
Technology
Pharma
Chemistry IPR
Toxicology
Know How
Assets in Kind
Technology
Private