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Viral M. Patel, MD, Marc Z. Handler, MD, Robert A

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Presentation on theme: "Viral M. Patel, MD, Marc Z. Handler, MD, Robert A"— Presentation transcript:

1 Hereditary leiomyomatosis and renal cell cancer syndrome: An update and review 
Viral M. Patel, MD, Marc Z. Handler, MD, Robert A. Schwartz, MD, MPH, DSc (Hon), W. Clark Lambert, MD, PhD  Journal of the American Academy of Dermatology  Volume 77, Issue 1, Pages (July 2017) DOI: /j.jaad Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

2 Fig 1 Cutaneous leiomyomas. Unilateral erythematous hyperpigmented nodules extensively involving the face and neck. Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

3 Fig 2 Segmental cutaneous leiomyomas.
Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

4 Fig 3 Cutaneous leiomyoma. Hematoxylin–eosin stain showing “cigar shaped” nuclei and bundles of smooth muscle cells. (Original magnification: ×40.) Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

5 Fig 4 Smooth muscle actin stain of a cutaneous leiomyoma showing staining of spindle cells. (Original magnification: ×40.) Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

6 Fig 5 Management algorithm for patients with hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome. CLM, Cutaneous leiomyoma; RCC, renal cell carcinoma; ULM, uterine leiomyoma. Journal of the American Academy of Dermatology  , DOI: ( /j.jaad ) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

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