2. fMRI Setup

3. slice orientations
sagittal
coronal
axial

4. SPGR Anatomics (1)
resolution
in-plane mm2
through-plane 1.5 mm

5. SPGR Anatomics (2)

6. SPGR Anatomics (3)
My notes for spgr movie

7. Diffusion-Weighted Imaging (1)

8. Diffusion-Weighted Imaging (2)

9. Diffusion-Weighted Imaging (3)

10. Slice Locations

11. Auditory versus Visual Sentence Task
common print(red) speech(blue)
R - L
Constable, Pugh et al., (NeuroImage 2004)

12. An Initial Neurobiological Reading Model
(Pugh et al. 2000)
TEMPOROPARIETAL
(DORSAL)
Areas:
supramarginal, angular, superior temporal (Wernicke’s) gyri
Hypothesized Function:
Mapping of orthographic to phonological and semantic representations
ANTERIOR
Areas:
inferior frontal gyrus (including Broca’s area)
One Hypothesized Function:
Articulatory recoding
OCCIPITOTEMPORAL (VENTRAL)
Areas:
occipitotemporal juncture,
middle and inferior temporal gyri
Hypothesized Function:
Linguistically structured memory-
based fast word identification system
(posterior aspect = “word-form” area)

13. Auditory versus Visual Sentence Task
common print(red) speech(blue)
temporoparietal
anterior
occipitotemporal
R - L
Constable, Pugh et al., (NeuroImage 2004)

14. Vasculature
Menon & Kim, Trends in Cognitive Sciences, 3(6), 1999.

15. Vasculature
Menon & Kim, Trends in Cognitive Sciences, 3(6), 1999.

16. Simulated Hemodynamic Response (1)
mean = 5000
sd = 100
effect size 0-1%, 0-50 points
Gamma function tau=1.08; n=3; delay=3

17. Variability of the HRF (1)
Meizin et al., 2000

18. Simulated Hemodynamic Response (2)
Noise SD = 0
Noise SD = 10
Noise SD = 100

19. Estimating the Response (3): Simple Subtraction with Overlap
Dale & Buckner, 1997
Add stim figure

20. Linear Deconvolution
Neuronal activity is modeled as a sequence of point events.
slide courtesy of Matthew Brown, University of Western Ontario

21. Functional Connectivity
activations in Shaywitz et al. 2002
older good readers
74 good readers 7-18 yrs
70 dyslexic readers 7-18 yrs

22. Functional Connectivity
seed voxel correlations
older good readers

23. Functional Connectivity
Younger Non-Impaired
Older Non-Impaired
univariate correlations
Younger Dyslexics
Older Dyslexics