1. Coronal (above) and axial (below) views of brain imaging findings in selected young onset dementias (images reproduced by kind permission of Dr Hadi Manji and Dr Nick Fox, Institute of Neurology).
Coronal (above) and axial (below) views of brain imaging findings in selected young onset dementias (images reproduced by kind permission of Dr Hadi Manji and Dr Nick Fox, Institute of Neurology). All images are presented in radiological convention (the left hemisphere is on the right). (A) Magnetic resonance imaging (MRI), T1 sequence of Alzheimer’s disease: disproportionate bilateral atrophy of hippocampi (white arrow). (B) MRI, T1 sequence, semantic dementia variant of frontotemporal lobar degeneration: disproportionate, asymmetric atrophy of anterior left temporal lobe. (C) MRI, T1 sequence, frontal variant of frontotemporal lobar degeneration: diffuse bilateral frontal atrophy relatively sparing temporal lobes. (D) MRI, fluid attenuated inversion recovery (FLAIR) sequence, paraneoplastic limbic encephalitis: focal bilateral alteration in mesial temporal lobe signal. (E) Computed tomogram, large frontal meningioma. (F) MRI, T1 sequence, small vessel disease: multiple lacunes in cerebral white matter and basal ganglia. (G) MRI, FLAIR sequence, cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL): bilateral abnormal high signal in anterior temporal lobes. (H) MRI, FLAIR sequence, new variant Creutzfeldt-Jakob disease (nvCJD): bilateral abnormal high signal focally affecting posterior thalami (“pulvinar sign”; white arrow).
E L Sampson et al. Postgrad Med J 2004;80:
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