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Inflammatory signals that regulate intestinal epithelial renewal, differentiation, migration and cell death: Implications for necrotizing enterocolitis 

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Presentation on theme: "Inflammatory signals that regulate intestinal epithelial renewal, differentiation, migration and cell death: Implications for necrotizing enterocolitis "— Presentation transcript:

1 Inflammatory signals that regulate intestinal epithelial renewal, differentiation, migration and cell death: Implications for necrotizing enterocolitis  Jegen Kandasamy, Shehzad Huda, Namasivayam Ambalavanan, Tamas Jilling  Pathophysiology  Volume 21, Issue 1, Pages (February 2014) DOI: /j.pathophys Copyright © 2014 Elsevier Ireland Ltd Terms and Conditions

2 Fig. 1 Schematic of intestinal epithelial differentiation. Adapted from Gerbe et al. [46]. Following the generation of new cells, intestinal epithelial cells must undergo differentiation, which occurs simultaneously with their migration out of the stem cell niche. Transcription factors that drive this differentiation as well as functions of the terminally differentiated, specialized epithelial cells are shown. Pathophysiology  , 67-80DOI: ( /j.pathophys ) Copyright © 2014 Elsevier Ireland Ltd Terms and Conditions

3 Fig. 2 The epithelial junctional complex. Adapted from Laukoetter et al. [49]. Pathophysiology  , 67-80DOI: ( /j.pathophys ) Copyright © 2014 Elsevier Ireland Ltd Terms and Conditions


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