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Finding Shangri-La: Limiting the Impact of Senescence on Aging

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Presentation on theme: "Finding Shangri-La: Limiting the Impact of Senescence on Aging"— Presentation transcript:

1 Finding Shangri-La: Limiting the Impact of Senescence on Aging
Sally E. Trabucco, Hong Zhang  Cell Stem Cell  Volume 18, Issue 3, Pages (March 2016) DOI: /j.stem Copyright © 2016 Elsevier Inc. Terms and Conditions

2 Figure 1 Targeting Senescence to Delay Aging and Prevent Age-Associated Diseases Inhibition of anti-apoptotic proteins leads to selective killing of senescent cells, whereas suppression of JAK results in inhibition of SASP. Both strategies rejuvenate aged stem cells and improve tissue functions in old mice. HSC, hematopoietic stem cell; MuSC, muscle stem cell; SASP, senescence-associated secretory phenotype. Cell Stem Cell  , DOI: ( /j.stem ) Copyright © 2016 Elsevier Inc. Terms and Conditions

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