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Oligonucleotide Delivery to the Lung: Waiting to Inhale

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Presentation on theme: "Oligonucleotide Delivery to the Lung: Waiting to Inhale"— Presentation transcript:

1 Oligonucleotide Delivery to the Lung: Waiting to Inhale
Jørgen Kjems, Kenneth A Howard  Molecular Therapy - Nucleic Acids  Volume 1, (January 2012) DOI: /mtna Copyright © 2012 American Society of Gene & Cell Therapy Terms and Conditions

2 Figure 1 Intratracheal delivery and macrophage capture of PS-LNA in the mouse lung based on the results obtained by Moschos et al.5 PS-LNA accumulates within macrophages and alveolar cells which further facilitated systemic migration to the kidney and liver. LNA, locked nucleic acid; PS, phosphorothioate. Molecular Therapy - Nucleic Acids 2012 1, DOI: ( /mtna ) Copyright © 2012 American Society of Gene & Cell Therapy Terms and Conditions

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