1. Nat. Rev. Neurol. doi:10.1038/nrneurol.2017.96
Figure 4 Patterns of brain atrophy in frontotemporal dementia syndromes
Figure 4 | Patterns of brain atrophy in frontotemporal dementia syndromes. The images show the patterns of atrophy observed on structural imaging in various frontotemporal dementia (FTD) syndromes, which arise from frontotemporal lobar degeneration. The core neuropsychiatric symptoms of behavioural variant FTD (bvFTD), such as apathy, disinhibition, eating disorders and aberrant motor behaviour, localize to right frontal structures. Patients with nonfluent/agrammatic variant primary progressive aphasia (nfvPPA) present with fluency impairment and/or agrammatism. These deficits localize to the frontoinsular language network, with atrophy noted most frequently in the left inferior frontal and insular cortices (the entire network is not depicted on this figure). In semantic variant PPA (svPPA), degeneration of the anterior temporal lobes disrupts access to semantic memory.
Elahi, F. M. & Miller, B. L. (2017) A clinicopathological approach to the diagnosis of dementia
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