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Direct epicardial shock wave therapy improves ventricular function and induces angiogenesis in ischemic heart failure  Daniel Zimpfer, MD, Seyedhossein.

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Presentation on theme: "Direct epicardial shock wave therapy improves ventricular function and induces angiogenesis in ischemic heart failure  Daniel Zimpfer, MD, Seyedhossein."— Presentation transcript:

1 Direct epicardial shock wave therapy improves ventricular function and induces angiogenesis in ischemic heart failure  Daniel Zimpfer, MD, Seyedhossein Aharinejad, MD, PhD, Johannes Holfeld, MS, Anita Thomas, MS, Julia Dumfarth, MD, Raphael Rosenhek, MD, Martin Czerny, MD, Wolfgang Schaden, MD, Mathias Gmeiner, MD, Ernst Wolner, MD, Michael Grimm, MD  The Journal of Thoracic and Cardiovascular Surgery  Volume 137, Issue 4, Pages (April 2009) DOI: /j.jtcvs Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

2 Figure 1 A, Direct epicardial shock wave therapy. B, Technical drawing of the applicator for direct epicardial shock wave therapy. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

3 Figure 2 A, Microvascular density and vessel size expressed as the number of vessels per field (± standard deviation) in the treatment and control groups 6 weeks after treatment. ∗P < .05, treatment versus control groups. B, Microvascular density and vessel size expressed as the number of vessels per field (± standard deviation) in the treatment and control groups 14 weeks after treatment. ∗P < .05, treatment versus control groups. C, Factor VIII staining of the anterior wall treatment group. D, Factor VIII staining of the anterior wall control group. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

4 Figure 3 A, Number of endothelial (Factor VIII–positive) cells per field (± standard deviation) 6 and 14 weeks after treatment in the treatment and control groups.Black bar Treatment group; white bar, control group. ∗P < .05, treatment versus control groups. B, Number of vital cells per field (± standard deviation) in the infarct scar 6 and 14 weeks after treatment in the treatment and control groups. Black bar, myocardial infarction with shock wave therapy; white bar, myocardial infarction without shock wave therapy. ∗P < .05, treatment versus control groups. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

5 Figure 4 Development of left ventricular function expressed as left ventricular ejection fraction (LVEF; percentage ± standard deviation) in the treatment and control groups. Solid line, Treatment group; dotted line, control group. ∗P < .05 compared with before left anterior descending artery (LAD) ligation. †P < .05, treatment versus control groups. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

6 Figure 5 A, Expression of vascular endothelial growth factor (VEGF) mRNA in the treatment and control groups 24 and 48 hours and 7 days after treatment. Black bar, Treatment group; white bar, control group. ∗P < .05, treatment versus control groups. B, Expression of Fms-related tyrosine kinase 1 (FLT1) mRNA in the treatment and control groups 24 and 48 hours and 7 days after treatment. Black bar, Treatment group; white bar, control group. ∗P < .05, treatment versus control groups. C, Expression of placental growth factor (PlGF) mRNA in the treatment and control groups 24 and 48 hours and 7 days after treatment. Black bar, Treatment group; white bar, control group. ∗P < .05, treatment versus control groups. D, Expression of vascular endothelial growth factor (VEGF) protein in the treatment and control groups 24 and 48 hours and 7 days after treatment. Black bar, Treatment group; white bar, control group. ∗P < .05, treatment versus control groups. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

7 Figure 6 Rat brain natriuretic peptide 45 serum levels expressed as picograms per milliliter (± standard deviation) 6 and 14 weeks after treatment in the treatment and control groups. Black bar, Treatment group; white bar, control group. ∗P < .05, treatment versus control groups. The Journal of Thoracic and Cardiovascular Surgery  , DOI: ( /j.jtcvs ) Copyright © 2009 The American Association for Thoracic Surgery Terms and Conditions

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