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A Cost-Effectiveness Analysis of Nivolumab versus Docetaxel for Advanced Nonsquamous NSCLC Including PD-L1 Testing  Klazien Matter-Walstra, PhD, Matthias.

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Presentation on theme: "A Cost-Effectiveness Analysis of Nivolumab versus Docetaxel for Advanced Nonsquamous NSCLC Including PD-L1 Testing  Klazien Matter-Walstra, PhD, Matthias."— Presentation transcript:

1 A Cost-Effectiveness Analysis of Nivolumab versus Docetaxel for Advanced Nonsquamous NSCLC Including PD-L1 Testing  Klazien Matter-Walstra, PhD, Matthias Schwenkglenks, MPH, Stefan Aebi, MD, Konstantin Dedes, MD, Joachim Diebold, MD, Mario Pietrini, Dirk Klingbiel, PhD, Roger von Moos, MD, Oliver Gautschi, MD  Journal of Thoracic Oncology  Volume 11, Issue 11, Pages (November 2016) DOI: /j.jtho Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

2 Figure 1 Model structure. PD-L1, programmed death ligand 1; C, chance node; M, Markov node. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

3 Figure 2 Probabilistic sensitivity analyses for nivolumab (NIV) versus docetaxel (DOC) and by programmed death ligand 1 (PD-L1) testing with a cutoff of 1% or more positive cells (PD-L1 ≥1%). PD-L1 ≥1% testing versus docetaxel (patients with positive test results receive nivolumab, patients with negative test results receive docetaxel) and PD-L1 ≥1% test versus nivolumab. QALY, quality-adjusted life-year; WTP, willingness-to-pay threshold. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

4 Figure 3 Tornado plot of the univariate sensitivity analyses for nivolumab (NIV) versus docetaxel (DOC). ICER, incremental cost-effectiveness ratio; QALY, quality-adjusted life-year; PFS, progression-free survival; OS, overall survival; FU, follow-up phase; FN, febrile neutropenia. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

5 Figure 4 Results of the nivolumab (NIV) cost reduction analyses. DOC, docetaxel; ICER, incremental cost-effectiveness ratio; QALY, quality-adjusted life years; WTP, willingness-to-pay threshold. Journal of Thoracic Oncology  , DOI: ( /j.jtho ) Copyright © 2016 International Association for the Study of Lung Cancer Terms and Conditions

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