1. Prospective evaluation of preoperative
Abstract ID: 
Moderated Poster - MP26
Prospective evaluation
of preoperative
Neutrophil/Lymphocyte ratio (NLR) as a prognosticator in
upper tract urothelial carcinoma (UTUC) patients treated conservatively
Defidio L1, De Dominicis M1, Di Gianfrancesco L2,, Antonucci M1, Patel A3
1Cristo Re Hospital, Dept. of Urology, Rome, Italy
2Catholic School of Medicine, Rome, Italy
3London, UK

2. Prospective evaluation of preoperative Neutrophil / Lymphocyte ratio as a prognosticator in upper tract urothelial carcinoma (UTUC) patients treated conservatively
NLR = expression of the involvement of systemic inflammation in neoplasia
Prospective pts. (Group 1: N=30) vs. Retrospective pts. (Group 2: N=130)
EAU guidelines follow-up scheme
WBC, PLT, N, L counts. (NLR = N / L).
Tumor Characteristics Compared : Grade, Stage, Focality, Site, Size.
Endpoints:
Recurrence at 1st follow-up
Multiple recurrences during follow-up
Progression (Grade-Stage)

3. In UTUC patients selected for renal conservation therapy
Prospective evaluation of preoperative Neutrophil / Lymphocyte ratio as a prognosticator in upper tract urothelial carcinoma (UTUC) patients treated conservatively
Mean NLR value: 2.90 ± 1.05 in Group 1 vs ± 1.92 in Group 2 (p=0.9).
Higher NLR values in:
≥pT1 (p=0.03 and p=0.0001)
HG (p=0.03 and p=0.0009)
Multifocal (p=0.01 and p=0.028)
>1 cm tumor (p=0.04 and p=0.0001)
NLR>3:
Rec. at 1st FU: p=0.04 (HR5.3) + p=0.007 (HR2.9)
Multiple Recs. in FU: p=0.02 (HR7.3) + p=0.006 (HR1.5)
Progression: p=0.04 (HR5) only in Group 2
In UTUC patients selected for renal conservation therapy
high baseline NLR may improve individualized care by identifying those who may need more frequent endoscopic follow-up, and those who should have lower thresholds to conversion to more aggressive surgical strategies.