1. Simulation of oxygen and substrate demands for ammonia detoxification.
Simulation of oxygen and substrate demands for ammonia detoxification. Analysis of oxygen demand for ammonia detoxification is based on the simulation ‘NH3 degradation’ (Supplementary Data 3.1) and the following settings: weight of the palmitate and glucose import is set to 10 and 100, respectively. The import flux of ammonia is set to 1. Export flux for urea iterates from 0 to 0.5 in 200 steps. Correspondingly, the export flux of glutamine ranges from 0 to 0.5 minus the export flux of urea. The export flux of alanine is set to the remaining nitrogen atoms: 1–2 × (export flux of urea+export flux of glutamine). Thus, the export of every atom imported with ammonium is fixed into predefined shares. (A) Oxygen demand as a function of the relative proportion of urea, glutamine and alanine as nitrogen compounds (arbitrary units). (B) Substrate demand, sum of glucose and palmitate fluxes. Fluxes are weighted by the number of carbon atoms in the substrate molecules, that is 6 (glucose) and 16 (palmitate). Plot axes as in (A).
Christoph Gille et al. Mol Syst Biol 2010;6:411
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