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A Few Good Commensals: Gut Microbes Use IFN-γ to Fight Salmonella

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Presentation on theme: "A Few Good Commensals: Gut Microbes Use IFN-γ to Fight Salmonella"— Presentation transcript:

1 A Few Good Commensals: Gut Microbes Use IFN-γ to Fight Salmonella
Kyla S. Ost, June L. Round  Immunity  Volume 46, Issue 6, Pages (June 2017) DOI: /j.immuni Copyright © Terms and Conditions

2 Figure 1 A Microbiota Community That Promotes IFN-γ Production Suppresses Salmonella enterica Serovar Typhimurium Tissue Invasion and Disease (Left) Comparing S. typhirium (S. Tm) disease severity in genetically identical mice with differing microbiota communities revealed that communities that induce Th1 cell, Th17 cell, IL-17, and IFN-γ production reduce Salmonella (S. Tm) tissue invasion and disease. (Right) Transferring small communities of cultured bacteria from the resistant SPF2 community (red) to mice harboring the sensitive SPF1 community (blue) recapitulates this immune response and ameliorates Salmonella invasion. Immunity  , DOI: ( /j.immuni ) Copyright © Terms and Conditions


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