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Peripheral T-Cell Lymphoma in 2013

Published byEarl Summers Modified over 5 years ago

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Presentation on theme: "Peripheral T-Cell Lymphoma in 2013"— Presentation transcript:

1 Peripheral T-Cell Lymphoma in 2013

2 Program Goal

3 WHO 2008 Classification of Mature T/NK-Cell Neoplasms

4 Use of the Term PTCL

5 PTCL, PTCL Mature (Post-Thymic) T-Cell Lymphomas

6 International PTCL Study: Major NHL Types by Region

7 Key Points in the Pathology Characteristics of the Most Common Subtypes of PTCL

8 ALK and ALCL

9 Outcomes by PTCL Subtypes

10 Prognostic Indices for PTCL

11 Autologous Stem Cell Transplantation as First-line Therapy in PTCL: Results of a Prospective Multicenter Study

12 CHOP: First-line Treatment of PTCL

13 Alemtuzumab (A) + Chemotherapy First-line treatment of PTCL

14 CHOP+ and Non-CHOP: First-line Treatment of PTCL

15 Treatment and Prognosis of Mature T-Cell and NK-Cell Lymphoma: Event-Free Survival of Younger Patients

16 Treatment and Prognosis of Mature T-Cell and NK-Cell Lymphoma: Event-free Survival of Younger Patients (cont)

17 Autologous Stem Cell Transplantation as First-line Therapy in PTCL: Survival

18 Prognostic Factors in Trials of ASCT in First Remission

19 ICE and Planned ASCT for Relapsed/ Refractory T-Cell Lymphoma: PFS From ICE

20 CIBMTR Auto and Allo for PTCL: Outcomes Excluding Patients in CR1

21 Retrospective Analyses of Allogeneic Stem-Cell Transplantation for PTCL

22 Approved Agents in Relapsed/Refractory PTCL

23 PROPEL: Adverse Events ≥ Gr 3 Occurring in ≥ 3% of Patients (n = 111)

24 Treatment-related Adverse Events With Romidepsin in ≥ 20% of Patients (N = 131)

25 Brentuximab Vedotin: Phase 2 Study in Relapsed/Refractory Systemic ALCL

26 Brentuximab Vedotin in Relapsed ALCL: Toxicities

27 Brentuximab: Best Clinical Response by Disease Diagnosis

28 Brentuximab: Maximum Tumor Volume Reduction by Frequency of CD30+ Cells

29 Front-line Therapy: Study Design (Combination Therapy Arms)

30 Front-line Therapy: Best Response by Disease Diagnosis

31 Bendamustine in T-Cell Lymphoma (BENTLY Trial)

32 Lenalidomide in Relapsed/Refractory TCL: Phase 2 Trial

33 Belinostat: PTCL Response Assessed by Central Review

34 Belinostat: Response Rate by CPRG Lymphoma Diagnosis

35 Belinostat: Grade ≥3 Nonhematologic AEs in Patients With R/R PTCL (N=120)

36 MLN8237: Response (PR + CR) by Histology

37 IPI-145: A PI3K-δ,γ Inhibitor

38 Early Signs of Clinical Activity of IPI-145 in T-Cell Lymphoma

39 Mogamulizumab (KW-0761) Anti-CCR4 Monoclonal Antibody

40 Recommended Approach to Patients With Relapsed PTCL (NOS, AITL, ALCL)

41 Abbreviations

42 Abbreviations (cont)

43 Abbreviations (cont)

44 Abbreviations (cont)

45 References

46 References (cont)

47 References (cont)

48 References (cont)

49 References (cont)

50 References (cont)

51 References (cont)

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