1. Three Decades of Structural Neuroimaging Methods
Bifrontal Ratio
Rating Scales (e.g., CERAD)
Linear Measures (e.g., Bicaudate Ratio)
Area Measures (e.g., Ventricle to Brain Ratio)
Bicaudate Ratio
Consortium to Establish a Registry for Alzheimer’s Disease
1980’s

2. putamen
caudate
1990’s
Manual Tracing of Basal Ganglia in Presymptomatic Huntington’s Disease

3. Automated Methods: Segmentation and Shape Analysis
“Autoworkup” and “Artificial NeuroNetwork from U. of Iowa
FSL programs for
automatic segmentation:
FIRST
FAST
Large Deformation Diffeomorphic Metric Mapping (LDDMM)
from Johns Hopkins