1. Vitamin E deficiency
Domina Petric, MD

2. PUFAs (polyunsaturated fatty acids)
Vitamin E deficiency
Vitamin E deficiency can result from insufficient dietary intake or impaired absorption of the vitamin.
Two most important dietary factors that affect the need for vitamin E are:
Selenium
PUFAs (polyunsaturated fatty acids)
11/18/2018
Combs GF. The Vitamins. Fundamental Aspects in Nutrition and Health. Elsevier Inc

3. Selenium spares the need for vitamin E.
Vitamin E deficiency
Selenium spares the need for vitamin E.
The dietary intake of PUFAs increases the need for vitamin E.
11/18/2018
Combs GF. The Vitamins. Fundamental Aspects in Nutrition and Health. Elsevier Inc

4. sulfur containing amino acids
Vitamin E deficiency
Other factors that can be expected to increase vitamin E needs are deficiencies of:
sulfur containing amino acids
copper
zinc
manganese
riboflavin
Vitamin E can be replaced by several lipid- soluble synthetic antioxidants and vitamin C.
11/18/2018
Combs GF. The Vitamins. Fundamental Aspects in Nutrition and Health. Elsevier Inc

5. Vitamin E deficiency
Conditions involving the malabsorption of lipids can also lead to vitamin E deficiency:
loss of pancreatic exocrine function (pancreatitis, pancreatic tumor, nutritional pancreatic atrophy in severe selenium deficiency)
lumenal deficiency of bile (biliary stasis due to mycotoxicosis, biliary atresia)
defects in lipoprotein metabolism (abetalipoproteinemia)
11/18/2018
Combs GF. The Vitamins. Fundamental Aspects in Nutrition and Health. Elsevier Inc

6. Vitamin E deficiency
Premature infants, who are typically impaired in their ability to utilize dietary fats, are also at risk of vitamin E deficiency.
Mutations in the α-TTP gene can produce tissue level vitamin E deficiency due to impaired uptake and transport of α-tocopherol:
low circulating tocopherol levels
progressive peripheral neuropathy-pathology of the large axons of sensory neurons and ataxia
11/18/2018
Combs GF. The Vitamins. Fundamental Aspects in Nutrition and Health. Elsevier Inc

7. Vitamin E deficiency
The targets of vitamin E deficiency are the neuromuscular, vascular and reproductive system.
The various signs of vitamin E deficiency are manifestations of membrane dysfunction resulting from the oxidative degradation of polyunsaturated membrane phospholipids and/or the disruption of other critical cellular processes.
11/18/2018
Combs GF. The Vitamins. Fundamental Aspects in Nutrition and Health. Elsevier Inc

8. Pharmacologic use
High levels of vitamin E may be appropriate in cases of oxidative stress.
Daily doses of IU/kg body weight prevent neurological abnormalities in cases of abetalipoproteinemia or chronic cholestasis.
Intakes of IU/day are needed by individuals with familial isolated vitamin E deficiency.
Supplements of 400 IU/day have been shown to support normal plasma tocopherol concentrations in patients with cystic fibrosis.
11/18/2018
Combs GF. The Vitamins. Fundamental Aspects in Nutrition and Health. Elsevier Inc

9. Literature
Combs GF. The Vitamins. Fundamental Aspects in Nutrition and Health. Elsevier Inc
11/18/2018