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Christine A. Sorkness, PharmD 

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Presentation on theme: "Christine A. Sorkness, PharmD "— Presentation transcript:

1 Establishing a therapeutic index for the inhaled corticosteroids: Part II 
Christine A. Sorkness, PharmD  Journal of Allergy and Clinical Immunology  Volume 102, Issue 4, Pages S52-S64 (October 1998) DOI: /S (98) Copyright © 1998 Mosby, Inc. Terms and Conditions

2 Fig. 1 Mechanisms of linear growth inhibition by GCs. Growth-suppressing influences of exogenous GCs on pulsatile GH secretion, IGF-1 bioactivity, GH-receptor expression, collagen synthesis, and adrenal androgen production (proposed) are depicted. GH , Growth hormone (pituitary), IGF-1 , insulin-like growth factor-1; GHRH , growth hormone releasing hormone (pituitary). Reproduced with permission from Allen DB. The influence of inhaled corticosteroids on growth: a pediatric endocrinologist’s perspective. Acta Paediatr 1997;86:1-7. Journal of Allergy and Clinical Immunology  , S52-S64DOI: ( /S (98) ) Copyright © 1998 Mosby, Inc. Terms and Conditions


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