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Oral Viscous Budesonide Is Effective in Children With Eosinophilic Esophagitis in a Randomized, Placebo-Controlled Trial  Ranjan Dohil, Robert Newbury,

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Presentation on theme: "Oral Viscous Budesonide Is Effective in Children With Eosinophilic Esophagitis in a Randomized, Placebo-Controlled Trial  Ranjan Dohil, Robert Newbury,"— Presentation transcript:

1 Oral Viscous Budesonide Is Effective in Children With Eosinophilic Esophagitis in a Randomized, Placebo-Controlled Trial  Ranjan Dohil, Robert Newbury, Lyman Fox, John Bastian, Seema Aceves  Gastroenterology  Volume 139, Issue 2, Pages e1 (August 2010) DOI: /j.gastro Copyright © 2010 AGA Institute Terms and Conditions

2 Figure 1 Individual pre- and post-treatment peak eosinophil (Eos) counts following 3 months' treatment with OVB and PPI (n = 15) and placebo plus PPI (n = 9). HPF, high-powered field; Tx, treatment. Gastroenterology  , e1DOI: ( /j.gastro ) Copyright © 2010 AGA Institute Terms and Conditions

3 Figure 2 Mean symptom scores during months 1, 2, and 3 of the study for patients in the OVB and placebo groups. Comparing changes from baseline, the mean symptom score improved significantly in the OVB group during months 1, 2, and 3, but not in the placebo group. Gastroenterology  , e1DOI: ( /j.gastro ) Copyright © 2010 AGA Institute Terms and Conditions

4 Figure 3 (A) Pretreatment distal esophageal mucosal biopsy. Above left, showing several intraepithelial eosinophils, basal zone hyperplasia, and intercellular edema (H&E ×200). Above right, lamina propria with fibrosis and eosinophilic inflammation (H&E ×400). (B) Post-treatment with OVB, distal esophageal biopsy from the same patient. Above left, unremarkable epithelium (H&E ×100). Above right shows lamina propria with no evidence of fibrosis or eosinophilic inflammation (H&E ×400). (C) Esophageal mucosal biopsies (×400 light microscopy) stained for profibrotic mediators showing LP in a responder patient. Upper images show transforming growth factor–β1 (TGFβ1)-positive (brown) cells and lower images show phosphorylated Smad2/3-positive (red) cells pre- and post-treatment with OVB. Gastroenterology  , e1DOI: ( /j.gastro ) Copyright © 2010 AGA Institute Terms and Conditions

5 Supplementary Figure 1 Flow diagram showing study patients.
Gastroenterology  , e1DOI: ( /j.gastro ) Copyright © 2010 AGA Institute Terms and Conditions


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