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Single-Center Experience of Unrelated and Haploidentical Stem Cell Transplantation with TCRαβ and CD19 Depletion in Children with Primary Immunodeficiency.

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Presentation on theme: "Single-Center Experience of Unrelated and Haploidentical Stem Cell Transplantation with TCRαβ and CD19 Depletion in Children with Primary Immunodeficiency."— Presentation transcript:

1 Single-Center Experience of Unrelated and Haploidentical Stem Cell Transplantation with TCRαβ and CD19 Depletion in Children with Primary Immunodeficiency Syndromes  Dmitry Balashov, Anna Shcherbina, Michael Maschan, Pavel Trakhtman, Yulia Skvortsova, Larisa Shelikhova, Alexandra Laberko, Anna Livshits, Galina Novichkova, Alexei Maschan  Biology of Blood and Marrow Transplantation  Volume 21, Issue 11, Pages (November 2015) DOI: /j.bbmt Copyright © Terms and Conditions

2 Figure 1 Cumulative incidence of grades II and IV acute GVHD (A) and probability of acute GVHD after haploidentical and unrelated HSCT (B). No patient had grade III acute GVHD. CI indicates cumulative incidence. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © Terms and Conditions

3 Figure 2 Cumulative probability of CMV reactivation for all patients (A) and CMV reactivation in haploidentical and unrelated HSCT recipients (B). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © Terms and Conditions

4 Figure 3 Probability of graft dysfunction (primary or secondary graft failure). (A) Graft failure after haploidentical and unrelated HSCT with conditioning regimens containing 1 alkylating agent (RIC). (B) Comparison of graft failure in groups with 1 and 2 alkylating agents in the conditioning regimen (RIC+Mel). RIC indicates reduced-intensity conditioning; Mel, melphalan. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © Terms and Conditions

5 Figure 4 Restoration of lymphocytes subpopulations after TCRαβ+/CD19+-depleted HSCT: (A) CD3+ cells; (B) αβ T cells; (C) naive T cells; (D) B cells. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © Terms and Conditions

6 Figure 5 Flow cytometry results in a patient with SCID after haploidentical TCRαβ+/CD19+-depleted HSCT. (A and B) CD3+ cells on day +60 (A) and day +120 (B) after HSCT. (C and D) Naive T cells on day +60 (C) and day +120 (D) after HSCT. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © Terms and Conditions

7 Figure 6 Probability of (A) event-free survival (EFS) and (B) cumulative incidence of overall survival (OS) in patients with PIDs after TCRαβ+/CD19+-depleted HSCT. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © Terms and Conditions

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