1. SIRIUS Trial: Diameter Restenosis
P<0.001
P=0.001
% Proximal Segment
% Distal Segment
% In Segment
% In stent
P=NS
P=0.14
Coated
Bare
Coated
Bare
Coated
Bare
Coated
Bare
Peristent Restenosis (PSR): 5 mm proximal and distal to the stent
In stent Restenosis (ISR): within the margins of the stent
In Segment: Sum of PSR and ISR
Euro PCR 2002

2. SIRIUS Trial: Late Loss (mm)
P=0.14
P=0.009
P=0.001
P<0.001
Distal Segment
In Segment
Proximal Segment
In stent
Coated
Bare
Coated
Bare
Coated
Bare
Coated
Bare
Peristent Restenosis (PSR): 5 mm proximal and distal to the stent
In stent Restenosis (ISR): within the margins of the stent
In Segment: Sum of PSR and ISR
Euro PCR 2002

3. SIRIUS Trial: Minimum Lumen Diameter at Follow-Up (mm)
In stent MLD (mm)
In stent MLD (mm)
In stent MLD (mm)
Coated
Bare
Coated
Bare
Coated
Bare
Small Vessels:
Median 2.30
Medium Vessels:
Median 2.79
Large Vessels:
Median 3.00
Euro PCR 2002

4. SIRIUS Trial: In Stent Restenosis at Follow-Up (%)
Coated
Bare
Coated
Bare
Coated
Bare
Small Vessels:
Median 2.30
Medium Vessels:
Median 2.79
Large Vessels:
Median 3.00
Euro PCR 2002

5. SIRIUS Trial: In Segment Restenosis at Follow-Up (%)
Coated
Bare
Coated
Bare
Coated
Bare
Small Vessels:
Median 2.30
Medium Vessels:
Median 2.79
Large Vessels:
Median 3.00
Euro PCR 2002

6. SIRIUS Trial: Lesion Length and IVUS Findings
Plaque Volume
NIH IVUS Volume
Restenotic Lesion Length (mm)
Coated
Bare
Coated
Bare
Coated
Bare
Euro PCR 2002

7. SIRIUS: Loss Index (Late Loss / Acute Gain)
In Stent
In Segment
Loss Index
Euro PCR 2002

8. Target Lesion Revasc (TLR) Target Vessel Failure (TVF)
SIRIUS: TLR and TVF
Target Lesion Revasc (TLR)
Target Vessel Failure (TVF)
P<0.001
P<0.001
Incidence (%)
Euro PCR 2002

9. SIRIUS: Clinical Events Stent Thrombosis < 24 hrs
Incidence (%)
Coated
Bare
Coated
Bare
Coated
Bare
Coated
Bare
Coated
Bare
Coated
Bare
Stent Thrombosis < 24 hrs
Stent Thrombosis Day
Death
Q wave MI
Non Q wave MI
MACE
Euro PCR 2002