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New Patient Journeys in Non-small cell lung cancer

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Presentation on theme: "New Patient Journeys in Non-small cell lung cancer"— Presentation transcript:

1 New Patient Journeys in Non-small cell lung cancer

2

3 Program Overview

4 Case #1: Immunotherapy in EGFR Mutation-Negative NSCLC

5 Testing for PD-L1 Expression: KEYNOTE-024

6 KEYNOTE-024: Results

7 Testing for PD-L1 Expression in the Clinic

8 Immune-Related AEs

9 Immune-Related Pneumonitis vs EGFR TKI-Associated ILD

10 Defining the Optimal Duration of Anti-PD-1/PD-L1 Therapy

11 KEYNOTE-010: Outcomes After 2 Years of Treatment

12 Determining the Optimal Treatment Schedule for Anti-PD-1/PD-L1 Therapy

13 Determining the Optimal Treatment Dose of Pembrolizumab

14 Case #2: Immunotherapy After EGFR TKI

15 Considerations in Using Immunotherapy in Previously Treated Patients

16 Second-line Nivolumab: CHECKMATE-057

17 Atezolizumab in Previously Treated NSCLC: OAK

18 Atezolizumab in Previously Treated NSCLC: OAK (cont)

19 Immunotherapy in Patients With EGFR Mutations

20 PD-L1 Expression in EGFR Mutation Positive Patients

21 PD-L1 Expression in EGFR Mutation Positive Patients (cont)

22 Immunotherapy in Patients With Brain Metastases

23 Pembrolizumab in Brain Metastatic NSCLC

24 Osimertinib in T790M-Mutant Brain Metastatic Disease

25 Osimertinib in EGFR-Mutant NSCLC and Leptomeningeal Disease

26 Combining Osimertinib and Immunotherapy

27 Conclusions

28 Abbreviations

29 Abbreviations (cont)


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