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Machines can work it out: Automated TrueAllele® workflow

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Presentation on theme: "Machines can work it out: Automated TrueAllele® workflow"— Presentation transcript:

1 Machines can work it out: Automated TrueAllele® workflow
Mid-Atlantic Association of Forensic Scientists May, 2017 Pittsburgh, PA William Allan, MS Mark W. Perlin, PhD, MD, PhD Cybergenetics, Pittsburgh, PA Cybergenetics © Cybergenetics ©

2 Technology

3 TrueAllele automation
While I am here, the computer is solving DNA mixture problems Versatile Accepts most sequencer and PCR kit data Productive Parallel processing works on multiple samples simultaneously Fast Results ready in hours

4 Workflow intake analyze request review report testify

5 Data too complex for lab interpretation
Case Data too complex for lab interpretation Sexual assault 2 evidence items 2 references PowerPlex® Fusion AB 3500 Forensic questions Is the suspect’s DNA present on the victim’s neck? Is the victim’s DNA present on the suspect’s underwear?

6 Evidence Victim’s neck swab Suspect’s underwear

7 Double, double toil and trouble
DNA mixing eye of newt toe of frog Double, double toil and trouble

8 Workflow intake analyze request review report testify

9 Analyze ladders size standards

10 Workflow intake analyze request review report testify

11 Data

12 Question 3 contributors 4 contributors

13 DNA unmixing eye of newt toe of frog No toil or trouble

14 TrueAllele processing
Describe TrueAllele system (left, middle, right, middle, left) ViewStation User Client Database Server Interpret/Match Expansion Visual User Interface VUIer™ Software Parallel Processing Computers Cybergenetics ©

15 Workflow intake analyze request review report testify

16 Mixture weight minor contributors major contributor

17 Evidence genotype Objective genotype determined solely from the DNA data. Never sees a comparison reference. 48% 16% 17% 5% 4% 3% 4%

18 Four independent computer runs
Genotype concordance Four independent computer runs with 3 or 4 contributors

19 Workflow intake analyze request review report testify

20 Match statistics nonillion trillion billion octillion Item Description
K1 Victim K2 Suspect Q1 Victim’s neck nonillion trillion Q2 Suspect’s underwear billion octillion

21 TrueAllele® computer technology
Accurate 34 validation studies, 7 published Objective Workflow removes human bias Accepted Reported in 37 states, used by labs Transparent Give math, software (4GB DVD) Neutral Can statistically include or exclude

22 Workflow intake analyze request review report testify

23 How the computer thinks
Consider every possible genotype solution Explain the peak pattern Better explanation has a higher likelihood One person's allele pair A third person's allele pair A second person's allele pair

24 How the computer thinks
Consider every possible genotype solution Worse explanation has a lower likelihood

25 How much more does the suspect match the evidence
DNA match information How much more does the suspect match the evidence than a random person? Prob(evidence match) Prob(coincidental match) 8x 48% 6%

26 Match information at 22 loci

27 Is the suspect in the evidence?
A match between the victim’s neck and the suspect is: 41.9 trillion times more probable than a coincidental match to an unrelated African-American person 8.45 trillion times more probable than a coincidental match to an unrelated Caucasian person 1.75 trillion times more probable than a coincidental match to an unrelated Hispanic person

28 Case outcome Prosecutor submitted the case to Cybergenetics via free screening offer Cybergenetics sent the prosecutor preliminary results in 2 weeks Prosecutor told Cybergenetics 3 weeks later that the suspect pled guilty

29 Allegheny County: 59 cases, 13 trials, 4 exonerations
Crime Evidence Defendant Outcome Sentence rape clothing Ralph Skundrich guilty 75 years murder gun, hat Leland Davis 23 years Akaninyene Akan 32 years shotgun shells James Yeckel, Jr. guilty plea 25 years fingernail Anthony Morgan life weapons gun Thomas Doswell 1 year bank robbery Jesse Lumberger 10 years drugs Derek McKissick 2 1/2 years Steve Morgan door, clothing Calvin Kane 20 years fingernail, clothing Allen Wade Jaykwaan Pinckney child rape Dhaque Jones 6 years shooting Anthony Jefferson 4 years Zachary Blair 15 years Delmingo Williams 3 years incest rape Terry L. 40 years hat Robert Schatzman 1 1/2 years Rashawn Walker 1.5 years robbery Lauren Peak body cavity Freddie Cole 2 years Chaz White sex crime Christopher Stavish Jake Knight

30 TrueAllele YouTube channel
More information • Courses • Newsletters • Newsroom • Presentations • Publications • Webinars TrueAllele YouTube channel

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