1. Care of the Treatment- experienced Patient With HCV Infection Who Failed Prior Therapy

2. Case 53-year-old Black Man

3. Case (cont)

4. Case (cont)

5. Case (cont)

6. Second Treatment Regimen

7. Case (cont)

8. Why Is Achieving SVR So Important?

9. Why Is Achieving SVR So Important?

10. Potential Treatment Options for the Case Patient

11. Simeprevir for Treatment-naive Patients

12. Simeprevir for Treatment-experienced Patients

13. Sofosbuvir

14. COSMOS Off-Label Combination of Sofosbuvir and Simeprevir  RBV in Patients With G1 HCV Infection

15. SAPPHIRE-I and SAPPHIRE-II ABT-450/r (protease inhibitor and ritonavir) + ABT-267 (NS5A inhibitor) + ABT-333 (non-nucleoside polymerase inhibitor) × 12 weeks

16. LONESTAR Trial Sofosbuvir and Ledipasvir Fixed-Dose Combination  RBV

17. Abbreviations

18. References

19. References (cont)