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Tacrolimus reduces urinary excretion of leukotriene E4 and inhibits aspirin-induced asthma to threshold dose of aspirin  Tetsuya Kawano, MD, Hiroto Matsuse,

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Presentation on theme: "Tacrolimus reduces urinary excretion of leukotriene E4 and inhibits aspirin-induced asthma to threshold dose of aspirin  Tetsuya Kawano, MD, Hiroto Matsuse,"— Presentation transcript:

1 Tacrolimus reduces urinary excretion of leukotriene E4 and inhibits aspirin-induced asthma to threshold dose of aspirin  Tetsuya Kawano, MD, Hiroto Matsuse, MD, Yuki Kondo, MD, Ikuko Machida, MD, Sachiko Saeki, MD, Shinya Tomari, MD, Kazuko Mitsuta, MD, Chizu Fukushima, MD, Yasushi Obase, MD, Terufumi Shimoda, MD, Shigeru Kohno, MD  Journal of Allergy and Clinical Immunology  Volume 114, Issue 6, Pages (December 2004) DOI: /j.jaci Copyright © 2004 American Academy of Allergy, Asthma and Immunology Terms and Conditions

2 Fig 1 Changes in urinary LTE4 before and after oral aspirin provocation test in patients pretreated with placebo or tacrolimus. Data are means ± SDs. ∗P < .01 vs. before the aspirin challenge test. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2004 American Academy of Allergy, Asthma and Immunology Terms and Conditions

3 Fig 2 Changes in urinary 11-dhTXB2 before and after oral aspirin provocation test in patients pretreated with placebo or tacrolimus. Data are means ± SDs. ∗P < .01 vs. before the aspirin challenge test. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2004 American Academy of Allergy, Asthma and Immunology Terms and Conditions


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