1. WG4: Stem Cells and Neurology
Biomaterials and advanced physical techniques for Regenerative Cardiology and Neurology (BIONECA)
WG4: Stem Cells and Neurology
Salvador Martinez. Instituto de Neurociencias CSIC-UMH. Alicante, Spain
Jose Maria Moraleda. Hematology Service. Hospital Univ. Arrixaca. Murcia, Spain
Clinical trials: BM-MNCs in ALS
Clinical Trial on the Use of Autologous Bone Marrow Stem Cells in Amyotrophic Lateral Sclerosis (CMN/ELA) - nº EudraCT: ,
Clinical Trials.gov NCT
- nº EudraCT: , EC 07/90762
NCT 
Murcia
Face I trial
11 patients
Randomized
Face II trial
63 patients
This approach will help achieve a standardization of transplant procedures
Main publication
Mouse NMR-7T
Human
TRDP43
control
grafted

2. WG4: Stem Cells and Neurology
Biomaterials and advanced physical techniques for Regenerative Cardiology and Neurology (BIONECA)
WG4: Stem Cells and Neurology
Improvement of motor cortex spectroscopy
Randomized side:
Cells/sham
Intramuscular graft of BM-MNCs
Mouse
Grafted side
Sham side
Intramuscular Infusion of Autologous Bone Marrow Stem Cells in Patients With Amyotrophic Lateral Sclerosis (TCIM/ELA)
DiI-retrog.
MNS
ClinicalTrials.gov Identifier: NCT
22 patients (17 males, 5 females).
Average evolution: 32 months