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Fluoroquinolones or macrolides in combination with β-lactams in adult patients hospitalized with community acquired pneumonia: a systematic review and.

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Presentation on theme: "Fluoroquinolones or macrolides in combination with β-lactams in adult patients hospitalized with community acquired pneumonia: a systematic review and."— Presentation transcript:

1 Fluoroquinolones or macrolides in combination with β-lactams in adult patients hospitalized with community acquired pneumonia: a systematic review and meta- analysis  K.Z. Vardakas, K.K. Trigkidis, M.E. Falagas  Clinical Microbiology and Infection  Volume 23, Issue 4, Pages (April 2017) DOI: /j.cmi Copyright © 2016 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

2 Fig. 1 Flow diagram of the selection process of the included studies.
Clinical Microbiology and Infection  , DOI: ( /j.cmi ) Copyright © 2016 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

3 Fig. 2 Forest plot depicting the unadjusted risk ratios (RR) of mortality among patients treated with β-lactam/fluoroquinolone (BLFQ) and β-lactam/macrolide (BLM) combinations. Vertical line represents ‘no difference’ point between the two regimens. Squares indicate risk ratios, Diamonds indicate pooled risk ratios for all studies. Horizontal lines represent 95% CI. Clinical Microbiology and Infection  , DOI: ( /j.cmi ) Copyright © 2016 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

4 Fig. 3 Funnel plot for studies providing outcomes for patients treated with β-lactam/macrolide (BLM) and β-lactam/fluoroquinolone (BLFQ) combination therapy (unadjusted analysis). Clinical Microbiology and Infection  , DOI: ( /j.cmi ) Copyright © 2016 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

5 Fig. 4 Forest plot depicting the adjusted risk ratios (RR) of mortality among patients treated with β-lactam/fluoroquinolone (BLFQ) and β-lactam/macrolide (BLM) combinations. Vertical line indicates ‘no difference’ point between the two regimens. Squares represent adjusted risk ratios. Diamonds represent pooled adjusted risk ratios for all studies. Horizontal lines represent 95% CI. Clinical Microbiology and Infection  , DOI: ( /j.cmi ) Copyright © 2016 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions


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