1. The Pathological Protein Ch 4, 5
BY Nicholas Toney

2. Connecting The Holes An Uncanny Resemblance Studying Scrapie
Hadlow - was Scrapie transmissible?
Studying Scrapie
Cuille and Chelle
15 month incubation period

3. Trying Transmissions Hadlow's Letter and Patuxent
Georgette's Sacrifice
"Their loss... was felt by the staff“
The Kuru-CJD Link
CJD experiments at Patuxent
Establishment of TSEs

4. End of an Epidemic Cannibalism in Kuru Cases of Kuru in early 2003
Implications?
Nobel Worthy
Gajdusek "fretted" that Zigas and Gibbs were not included

5. The Birth of the Prion
The Central Dogma

6. A Tough Invader Tikvah Alper The Elusive Agent Radiation experiments
High energy electrons
Ultraviolet radiation
The Elusive Agent
Central Dogma maintained
Thoertical model proposed by mathmeticain

7. TSE's New Player Pruisner Persevered New Methodology
Isolation of the Agent
Protease Sensitivity
Filtered at kDa250 Amino Acid Minimum
Maximum of 50 nucleotides

8. The Virus Paradox

9. The Prion Proposal Controversy over Pruisner's work
Frank Masiarze refused Co-Authorship
Nature and Lancet soon published rebuttals
Fatal Filaments Patricia Merz
Filaments associated with Scrapie
Manuelidis
CJD confirmed Amyloid plaques?

10. The Normal and the Diabolical
DNA sequencing as a tool to find the causative agent
Pruisiner found that the scrapie agent existed in healthy and infected brains
Proteinase K - protein differentiation