1. Volume 52, Issue 1, Pages 116-125 (July 2007)
Relative Copy Number Gain of MYC in Diagnostic Needle Biopsies is an Independent Prognostic Factor for Prostate Cancer Patients 
Franclim R. Ribeiro, Rui Henrique, Ana T. Martins, Carmen Jerónimo, Manuel R. Teixeira 
European Urology 
Volume 52, Issue 1, Pages (July 2007)
DOI: /j.eururo
Copyright © 2006 European Association of Urology Terms and Conditions

2. Fig. 1
Disease-specific survival curves using established clinical variables. (A) Cases grouped according to clinical stage at diagnosis. (B) Cases grouped by Gleason score categories.
European Urology  , DOI: ( /j.eururo )
Copyright © 2006 European Association of Urology Terms and Conditions

3. Fig. 2
Representative fluorescent in situ hybridization images from selected prostate biopsies analyzed with a dual-color (green and red) MYC probe and a chromosome 18 centromeric probe (blue). Cells presenting MYC/CEP18 ratios of 1.0 (A and B), 1.5 (C), 3.0 (D), 2.0 (E), 2.5 (F), and 2.3 (G) are presented (sample identifications (IDs): B13, B12, B27, B22, B26, B23, and B28, respectively; see Table 2).
European Urology  , DOI: ( /j.eururo )
Copyright © 2006 European Association of Urology Terms and Conditions

4. Fig. 3
Fluorescent in situ hybridization (FISH) patterns indicative of MYC rearrangements in prostate carcinoma biopsies. (A) Nuclei with three centromeric signals for chromosome 18 (blue), two dual-color (green and red) signals representing normal copies of MYC, and one additional MYC3′ signal (sample identification [ID]: B08). (B) Nuclei showing amplifications of MYC5′, in addition to the two normal copies of MYC (sample ID: B16). (C) Nuclei presenting a slight separation of MYC3′ and MYC5′ probes suggesting an intrachromosomal rearrangement affecting this gene (sample ID: B31). (D) Nuclei with a FISH pattern suggesting an internal duplication within one of the MYC genes (sample ID: A07). (E) Nuclei with a break-apart pattern suggesting a translocation affecting the MYC gene (sample ID: A04).
European Urology  , DOI: ( /j.eururo )
Copyright © 2006 European Association of Urology Terms and Conditions

5. Fig. 4
Disease-specific survival curves based on 8q status assessed by three-color fluorescent in situ hybridization. (A) All cases, grouped according to the respective MYC/CEP18 ratio. (B) Samples with Gleason score=7. (C) Samples from patients with clinical stage II or III disease at diagnosis.
European Urology  , DOI: ( /j.eururo )
Copyright © 2006 European Association of Urology Terms and Conditions