Presentation is loading. Please wait.

Presentation is loading. Please wait.

Louise E. Glover, Sean P. Colgan  Gastroenterology 

Similar presentations


Presentation on theme: "Louise E. Glover, Sean P. Colgan  Gastroenterology "— Presentation transcript:

1 Hypoxia and Metabolic Factors That Influence Inflammatory Bowel Disease Pathogenesis 
Louise E. Glover, Sean P. Colgan  Gastroenterology  Volume 140, Issue 6, Pages (May 2011) DOI: /j.gastro Copyright © 2011 AGA Institute Terms and Conditions

2 Figure 1 Contributions of inflammation and hypoxia to angiogenesis. Inflammation and hypoxia each contribute to angiogenesis during pathogenesis of IBD, partly by induction of vascular endothelial growth factor (VEGF)-A expression in multiple cell types that include submucosal fibroblasts, macrophages, neutrophils (PMNs), and endothelial cells. VEGF-A–induced angiogenesis is likely to be pathogenic and result in abnormal vessel formation and poorly functioning vasculature. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2011 AGA Institute Terms and Conditions

3 Figure 2 Functional features of HIF and mechanism of HIF stabilization. HIF is hydroxylated by the combination of α-ketoglutarate (αKG), molecular oxygen (O2), and the PHD enzymes in normoxic conditions. When O2 becomes limiting (hypoxia), the HIF α subunit is stabilized and binds to the HIF-1 β subunit in the nucleus; the complex binds to the HRE in target genes to regulate their transcription. Gastroenterology  , DOI: ( /j.gastro ) Copyright © 2011 AGA Institute Terms and Conditions

4 Gastroenterology 2011 140, 1748-1755DOI: (10. 1053/j. gastro. 2011. 01
Copyright © 2011 AGA Institute Terms and Conditions

5 Gastroenterology 2011 140, 1748-1755DOI: (10. 1053/j. gastro. 2011. 01
Copyright © 2011 AGA Institute Terms and Conditions


Download ppt "Louise E. Glover, Sean P. Colgan  Gastroenterology "

Similar presentations


Ads by Google