Download presentation
Presentation is loading. Please wait.
Published byAlexis Léger Modified over 6 years ago
1
Hypoxia and Metabolic Factors That Influence Inflammatory Bowel Disease Pathogenesis
Louise E. Glover, Sean P. Colgan Gastroenterology Volume 140, Issue 6, Pages (May 2011) DOI: /j.gastro Copyright © 2011 AGA Institute Terms and Conditions
2
Figure 1 Contributions of inflammation and hypoxia to angiogenesis. Inflammation and hypoxia each contribute to angiogenesis during pathogenesis of IBD, partly by induction of vascular endothelial growth factor (VEGF)-A expression in multiple cell types that include submucosal fibroblasts, macrophages, neutrophils (PMNs), and endothelial cells. VEGF-A–induced angiogenesis is likely to be pathogenic and result in abnormal vessel formation and poorly functioning vasculature. Gastroenterology , DOI: ( /j.gastro ) Copyright © 2011 AGA Institute Terms and Conditions
3
Figure 2 Functional features of HIF and mechanism of HIF stabilization. HIF is hydroxylated by the combination of α-ketoglutarate (αKG), molecular oxygen (O2), and the PHD enzymes in normoxic conditions. When O2 becomes limiting (hypoxia), the HIF α subunit is stabilized and binds to the HIF-1 β subunit in the nucleus; the complex binds to the HRE in target genes to regulate their transcription. Gastroenterology , DOI: ( /j.gastro ) Copyright © 2011 AGA Institute Terms and Conditions
4
Gastroenterology 2011 140, 1748-1755DOI: (10. 1053/j. gastro. 2011. 01
Copyright © 2011 AGA Institute Terms and Conditions
5
Gastroenterology 2011 140, 1748-1755DOI: (10. 1053/j. gastro. 2011. 01
Copyright © 2011 AGA Institute Terms and Conditions
Similar presentations
© 2024 SlidePlayer.com Inc.
All rights reserved.