1. 16 November 2009 Cardiovascular Physiology
Lab this week: Frog Heart Physiology Bring Textbook to lab.
Test # 3 is Monday, Nov 23rd.

2. Mean Arterial Pressure = Cardiac Output x Total Peripheral Resistance
MAP = CO x TPR
MAP = (HR x SV) x TPR

3. Fig
12.50.jpg

4. Receptors for other ligands
Alpha receptors more common except in skeletal muscle arterioles which have more B2 receptors

5. Fig. 12.36 3 No parasympathetic innervation of arterioles!
Metabolic vasodilators
No parasympathetic innervation of arterioles!
Importance of sympathetic “tone.”
12.36.jpg
Metabolic autoregulation, flow autoregulation, myogenic autoregulation

6. Figure 12.02 4 Arteries = 10% of Blood Volume
Veins = 60% of Blood Volume
Arterioles = Resistance vessels
Capillaries = 5% of Blood Volume

7. 5
Capillaries: Continuous, discontinuous, and fenestrated capillaries:
Ex: brain and liver
Figure 12.38
Generate vasodilators and vasoconstrictors
Arterioles:
1) Extrinsic control by hormones and nerves 2) Intrinsic (local) control by …..a) metabolic autoregulation, …..b) flow autoregulation, and …..c) myogenic autoregulation.

8. Diffusion, mediated transport, bulk flow8
Diffusion, mediated transport, bulk flow

9. Diffusion is the most important mode of exchange of nutrients7
Fig
Diffusion is the most important mode of exchange of nutrients
12.40.jpg

10. 9
Figure 12.41
Colloids
Crystalloids
Bulk Flow

11. 10
Figure 12.42
Bulk Flow through aqueous channels and intracellular clefts
Starling Forces
Regulated by arterioles
Net filtration = 4L/day
Main difference in the Pulmonary circuit?

12. Fig Pc Pc
12.43.jpg Pc

13. Fate of 4 L/d excess filtrate12
Figure 12.47
Fate of 4 L/d excess filtrate
Liver &
Bone Marrow

14. Figure 12.47

15. Physiology of support hose
Who Cares? 11
Aunt Esther
Physiology of support hose

16. Figure 12.60
Orthostatic Hypotension

17. Arteries are low compliance13
Figure 12.44
Veins are Capacitance vessels (high compliance) with valves for unidirectional flow
Arteries are low compliance

18. Fig
MAP = CO x TPR
Negative feedback control: stimulus, receptors, afferent pathway(s), integrator, efferent pathway(s), effector(s) response(s)
12.53.jpg