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Hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation: donor type matters by Maha El-Zimaity, Rima Saliba, Kawah Chan, Munir Shahjahan,

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Presentation on theme: "Hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation: donor type matters by Maha El-Zimaity, Rima Saliba, Kawah Chan, Munir Shahjahan,"— Presentation transcript:

1 Hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation: donor type matters
by Maha El-Zimaity, Rima Saliba, Kawah Chan, Munir Shahjahan, Antonio Carrasco, Ola Khorshid, Humberto Caldera, Daniel Couriel, Sergio Giralt, Issa Khouri, Cindy Ippoliti, Richard Champlin, and Marcos de Lima Blood Volume 103(12): June 15, 2004 ©2004 by American Society of Hematology

2 Cumulative incidence of hemorrhagic cystitis by donor type.
Cumulative incidence of hemorrhagic cystitis by donor type. Cumulative incidence was similar for all subgroups during the first month after transplantation; excessive incidence among MUD, MM rel, and UCB became evident after that time period. No cases of hemorrhagic cystitis were documented among matched related donor transplantations after the first month. Cumulative incidence of HC was as follows: MRD, 16% (95% CI 7-35); MM rel, 30% (95% CI 16-58); MUD, 40% (95% CI 27-60); and UCB, 40% (95% CI 22-74). MUD indicates matched unrelated donor; UCB, unrelated cord blood; MM rel, mismatched related (1 antigen mismatch); MRD, matched related donor. Maha El-Zimaity et al. Blood 2004;103: ©2004 by American Society of Hematology

3 Cumulative incidence of hemorrhagic cystitis by recipient age.
Cumulative incidence of hemorrhagic cystitis by recipient age. Patients younger than 26 had a cumulative incidence of HC of 40% (95% CI 27-59), while those older than 25 had a cumulative incidence of 18% (95% CI 9-35). Maha El-Zimaity et al. Blood 2004;103: ©2004 by American Society of Hematology


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