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Influence of GST Gene Polymorphisms on the Clearance of Intravenous Busulfan in Adult Patients Undergoing Hematopoietic Cell Transplantation  Sung-Doo.

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Presentation on theme: "Influence of GST Gene Polymorphisms on the Clearance of Intravenous Busulfan in Adult Patients Undergoing Hematopoietic Cell Transplantation  Sung-Doo."— Presentation transcript:

1 Influence of GST Gene Polymorphisms on the Clearance of Intravenous Busulfan in Adult Patients Undergoing Hematopoietic Cell Transplantation  Sung-Doo Kim, Je-Hwan Lee, Eun-Hye Hur, Jung-Hee Lee, Dae-Young Kim, Sung-Nam Lim, Yunsuk Choi, Hyeong-Seok Lim, Kyun- Seop Bae, Gyu-Jeong Noh, Sung-Cheol Yun, Sang Beom Han, Kyoo-Hyung Lee  Biology of Blood and Marrow Transplantation  Volume 17, Issue 8, Pages (August 2011) DOI: /j.bbmt Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Comparison of busulfan clearance distribution according to GST genotypes. Horizontal lines indicate the means of each group. (A) GSTA1, (B) GSTM1, (C) GSTT1, and (D) GSTM1/GSTT1-null genotype (ie, the number of GSTM1- and GSTT1-null genotypes). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Clearance of i.v. busulfan according to GST gene polymorphism. Horizontal lines indicate the means of each group. Busulfan clearance was grouped by GSTA1 genotype and GSTM1/GSTT1-null genotype (ie, the number of GSTM1- and GSTT1-null genotypes). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

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