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Are good patient and embryo characteristics protective against the negative effect of elevated progesterone level on the day of oocyte maturation?  Micah.

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Presentation on theme: "Are good patient and embryo characteristics protective against the negative effect of elevated progesterone level on the day of oocyte maturation?  Micah."— Presentation transcript:

1 Are good patient and embryo characteristics protective against the negative effect of elevated progesterone level on the day of oocyte maturation?  Micah J. Hill, D.O., Greene Donald Royster, M.D., Mae Wu Healy, D.O., Kevin S. Richter, Ph.D., Gary Levy, M.D., Alan H. DeCherney, M.D., Eric D. Levens, M.D., Geeta Suthar, B.S.M.T., C.L.C.P., Eric Widra, M.D., Michael J. Levy, M.D.  Fertility and Sterility  Volume 103, Issue 6, Pages e5 (June 2015) DOI: /j.fertnstert Copyright © Terms and Conditions

2 Figure 1 Graphic representation of the effect of serum P values on implantation and live birth in cleavage and blastocyst embryo transfers. Progesterone values (ng/ml) are plotted on the x-axis, and implantation (A and B) and live birth (C and D) are on the y-axis. Actual implantation (A) and live birth (C) are shown per serum P value. Linear trend lines for implantation (B) and live birth (D) are shown per serum P value. hCG = human chorionic gonadotropin; P = progesterone. Fertility and Sterility  , e5DOI: ( /j.fertnstert ) Copyright © Terms and Conditions

3 Figure 2 Graphic representation of the effect of serum P values on implantation and live birth in good blastocyst and fair or poor blastocyst embryo transfers. Progesterone values (ng/ml) are plotted on the x-axis, and implantation (A and B) and live birth (C and D) are indicated on the y-axis. Actual implantation (A) and live birth (C) are shown per serum P value. Linear trend lines for implantation (B) and live birth (D) are shown per serum P value. hCG = human chorionic gonadotropin; P = progesterone. Fertility and Sterility  , e5DOI: ( /j.fertnstert ) Copyright © Terms and Conditions

4 Figure 3 Graphic representation of the effect of serum P values on implantation and live birth based on ovarian response. Progesterone values (ng/ml) are plotted on the x-axis, and implantation (A and B) and live birth (C and D) are indicated on the y-axis. Actual implantation (A) and live birth (C) are shown per serum P value. Linear trend lines for implantation (B) and live birth (D) are shown per serum P value. hCG = human chorionic gonadotropin; P = progesterone. Fertility and Sterility  , e5DOI: ( /j.fertnstert ) Copyright © Terms and Conditions

5 Supplemental Figure 1 Distribution of patients across ranges of serum P levels (ng/ml) on the day of hCG administration. hCG = human chorionic gonadotropin. Fertility and Sterility  , e5DOI: ( /j.fertnstert ) Copyright © Terms and Conditions

6 Supplemental Figure 2 Patient age, total medication dosage, and serum estradiol and progesterone concentrations at the point of trigger were complexly interrelated, as illustrated in this figure, which indicates statistically significant associations, along with regression (B) and correlation (r) coefficients. IU = international unit. Fertility and Sterility  , e5DOI: ( /j.fertnstert ) Copyright © Terms and Conditions

7 Supplemental Figure 3 Graphic representation of the effect of serum P values on implantation and live birth in good-cleavage and fair- or poor-cleavage embryo transfers. Progesterone values (ng/ml) are plotted on the x-axis, and implantation (A and B) and live birth (C and D) are indicated on the y-axis. Actual implantation (A) and live birth (C) are shown per serum P value. Linear trend lines for implantation (B) and live birth (D) are shown per serum P value. hCG = human chorionic gonadotropin; P = progesterone. Fertility and Sterility  , e5DOI: ( /j.fertnstert ) Copyright © Terms and Conditions

8 Supplemental Figure 4 Graphic representation of the effect of serum P values on implantation and live birth, based on patient age. Progesterone values (ng/ml) are plotted on the x-axis, and implantation (A and B) and live birth (C and D) are indicated on the y-axis. Actual implantation (A) and live birth (C) are shown per serum P value. Linear trend lines for implantation (B) and live birth (D) are shown per serum P value. The color-coded range values indicate patient age groups, in years. hCG = human chorionic gonadotropin; P = progesterone. Fertility and Sterility  , e5DOI: ( /j.fertnstert ) Copyright © Terms and Conditions

9 Supplemental Figure 5 Graphic representation of the effect of serum P values on implantation and live birth based on GnRH-agonist and GnRH-antagonist protocols. Progesterone values (ng/ml) are plotted on the x-axis, and implantation (A and B) and live birth (C and D) are indicated on the y-axis. Actual implantation (A) and live birth (C) are shown per serum P value. Linear trend lines for implantation (B) and live birth (D) are shown per serum P value. GnRH = gonadotropin releasing hormone; hCG = human chorionic gonadotropin; P = progesterone. Fertility and Sterility  , e5DOI: ( /j.fertnstert ) Copyright © Terms and Conditions


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