1. Pathophysiology of Irritable Bowel Syndrome

2. Rome III Criteria: Irritable Bowel Syndrome

3. A Renaissance in Understanding Causes of IBS

4. IBS-C Mimics Evacuation Disorder

5. Peripheral Mechanism: Altered Colonic Motility

6. Abnormal Transit in Diarrhea and in Constipation

7. Bile Acids in IBS-C and IBS-D

8. Peripheral Mechanism: Small Bowel and Colonic Sensing and Response

9. Peripheral Mechanism: Small Bowel Mucosal Permeability

10. Layers of Protection: Intestinal Mucosa

11. Peripheral Mechanism: Colonic Mucosal Permeability

12. Peripheral Mechanism: Mucosal Immune Activation

13. Peripheral Mechanism: Colonic Microbiome

14. Current Treatment Is Guided by Symptom-Based Diagnostic Criteria

15. IBS Symptoms: Mechanisms and Diagnosis

16. Actions of Treatments Based on Pathophysiology

17. Diagnostic Implications

18. Future Research

19. Future Research (cont)

20. Abbreviations

21. References

22. References (cont)