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Mineral and bone disorders in chronic kidney disease and end-stage renal disease patients: new insights into vitamin D receptor activation Jordi Bover, Mario Cozzolino Kidney International Supplements Volume 1, Issue 4, Pages (September 2011) DOI: /kisup Copyright © 2011 International Society of Nephrology Terms and Conditions
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Figure 1 The interrelated nature of biochemical abnormalities, bone disease, and extraskeletal calcification in chronic kidney disease–mineral and bone disorder. Reprinted from Moe et al.,14 copyright 2011, with permission from Elsevier. CVD, cardiovascular disease. Kidney International Supplements 2011 1, DOI: ( /kisup ) Copyright © 2011 International Society of Nephrology Terms and Conditions
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Figure 2 Reduced VDR activation and outcome. The reduction of VDR activation is associated with multiple deleterious effects in different systems leading to an increase in mortality. RAS, renin–angiotensin system; SHPT, secondary hyperparathyroidism; VDR, vitamin D receptor. Kidney International Supplements 2011 1, DOI: ( /kisup ) Copyright © 2011 International Society of Nephrology Terms and Conditions
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