1. Virsuses: Human Immunodeficiency Syndrome & Acquired Immunodeficiency Syndrome

2. Topics to cover • HIV • AIDS Origins Transmission and replication
Detection and treatments
• AIDS

3. Dr. Beatrice Hahn &
colleagues:
Drs. Li and Keele

4. Red Capped Mangabey monkey
Greater spot nose monkey
SIV cpz almost identical to HIV 1
Humans

5. Pan troglodytes troglodytes
Simian Virus (SIV cpz) almost identical to HIV 1

7. HIV

8. T lymphocyte in green and HIV in red

9. HIV: Structure and
mechanism of replication

10. HIV-1 PARTICLE

11. Transmission of HIV

12. RETROVIRAL REPLICATION

13. HIV and helper T cells HOST CELLS: helper T lymphocyte, macrophages

14. Budding of HIV from T lymphocyte

15. Mechanism of Infection
Infects Th cell
VIRAL RNA
Integrates into host DNA
“activated”
PROVIRAL DNA
LYTIC STAGE
storage
LYSOGENIC STAGE