1. Optimal Immune System Support
Product Training

2. The Human Immune System
...…is a complicated network of cells, antibodies and proteins that serves following three main functions:
1. Removes waste and harmful material, to ensure the normal function of the body.
2. Defends against pathogens - bacteria, fungi and virus.
3. Kills and removes dead and altered cells.

3. The Human Immune System
......is delicately balanced by a very sophisticated feedback regulation and control system
Prolonged immune deficiency can lead to infection, frequent sickness, lack of vigor and energy and impaired metabolism.
On the other hand, chronic activation of immune system can also lead to certain autoimmune conditions such as arthritis, lupus, nephritis, allergy, etc.

4. Immune Cells Recognize and Destroy: Pathogens and Altered Cells
Chemical message alerts immune system that an invader is present
Immune cell “swallows” foreign invader

5. Reishi Mushroom
Reishi (Ganoderma lucidum) mushroom is a fungus occurring as a shelf-like form on the sides of trees and stumps in densely wooded mountains with high humidity and low light.
The spores of Reishi have such tough outer husks that germination is next to impossible, which accounts for its rarity.
The Reishi mushroom is a fungus that occurs as a shelf-like form on the sides of trees and stumps. In nature it grows in densely wooded mountains with high humidity and low light. It is rarely found since it flourishes mainly on the dried trunks of dead plum pasonia trees.
The spores of Reishi also have such tough outer husks that make germination next to impossible. This accounts for its rarity.

6. Types of Reishi
There are 62 types of Reishi, of which six are most common:
RED BLACK
BLUE WHITE
YELLOW PURPLE
RED Reishi is preferred because it can produce the highest quality extract and has been subject to the most scientific evaluation
There are 62 types of Reishi, of which six are most common: red, blue, yellow, black, white and purple. Pharmanex has chosen to use red Reishi in ReishiMax because it can produce the highest quality extract and has been subject to the most scientific evaluation.

7. Traditional Use
Reishi, also known as Lingzhi, is one of the most valued herbal products in Traditional Chinese Medicine (TCM)
Reishi’s earliest herbal remedies were recorded between 206 B.C. - 8 A.D.
In Taiwan, families often give Reishi to their aging grandparents
Reishi is also known as Lingzhi. It is one of the earliest herbal remedies that has been recorded between the years of 206 B.C.-8A.D, and it is one of the most valued and potent herbal products used in Traditional Chinese Medicine. In China, Reishi is a Traditional Chinese Medicine herb of choice as a general tonic for promoting longevity, vitality and endurance, and general health preservation.

8. Cultivation of Reishi
In 1971, Yukio Naoi, a researcher of the Kyoto University in Japan, successfully developed the artificial cultivation of Reishi, which resulted in reproducible and consistent production of Reishi.
A new cultivation method by Yukio Naoi from the University of Japan increased the availability of Reishi to everyone. This cultivation method resulted in the ability to cultivate Reishi in large quantities. And because the Reishi is cultivated in a controlled environment, it is free of pollutants.
The Reishi strain is transplanted to the cut of the original wood, so that the Reishi can absorb the nutrients of the wood The cultivation period takes between days. This method makes it very similar to the natural habitat of wild Reishi.

9. Reishi Spores
These highly active substances are the essence of Reishi.
They are the reproductive cells that are released at maturity.
However, Reishi spores are protected by an extremely hard shell which prevent us from optimally absorbing the actives.
Reishi spores contain the reproductive cells that are released at maturity. Unfortunately, the outer shells of the mushroom make it extremely hard to obtain these spores and prevent us from optimally absorbing the actives therein.

10. Compounds Identified in Reishi Mushrooms

11. Research Findings: Reishi Mushroom & Extracts
Cell support
Immune dysfunction-related diseases
Liver protection
Nervous system dysfunction
Cardiovascular protection and blood sugar support

12. Clinical studies on Reishi
Reishi stimulates the immune system’s ability to recognize pathogens and altered cells
Reishi provides complementary therapy to promote health and longevity
stimulates the formation of antibodies
stimulates the ability of proliferation of immune cells
modulates the function of T cells and NK cells
Wang SY, et al. International Journal of Cancer 1997;70(6): Lu Z, Lin ZB International Symposium on Ganoderma Research, October 24-26, 1994, Beijing Medical University, Beijing , China, Program and Abstracts, p. 82.
Kupin, V. (1992). The 4th International Symposium on Ganoderma lucidum, Hyatt Regency hotel, June 10, 1992, Seoul, Korea, Program and Abstracts, pp Yang QY, Wang, M. M. (1996) Taipei International Ganoderma Research Conference, Taipei International Convention Center (TICC), August 15-15, 1996, Abstracts, Special Lecture.

13. Optimal Immune System Support
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

14. Uses the best Reishi species: RED Reishi or Ganoderma lucidum
Use of the best Reishi cultivation method:
solid tree trunk, organic cultivation for days
Free of heavy metals and unwanted microbial contamination
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

15. Uses Pharmanex’s proprietary manufacturing process
to extract active components from Reishi
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

16. Reishi spores 100% Cracked spores
Cracked Reishi Spores
Reishi spores % Cracked spores
— 3000X magnification under an electronic microscope
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

17. Proprietary Formula Contains Reishi spores (100% cracked)
Standardized to
6% Reishi triterpenes
13.5% Reishi polysaccharides
ReishiMax follows the 6S process with standardization. ReishiMax is standardized to the highest level of actives found in any Reishi extract.
The actives ingredients found in Reishi are triterpenes and polysaccharides. These two actives make Reishi a potent herb. ReishiMax is standardized to 6% triterpenes and 13.5% polysaccharides.
Not only does Reishimax contain these active ingredients, but our product contains a 1% extract of 100% cracked spores!

18. ReishiMax Clinical Studies
A comparative study demonstrated enhanced immune functions by ReishiMax:
Increased serum antibodies*
Stimulated proliferation of immune cells*
Modulation of the T cell functions*
Enhanced the NK cell functions*
According to the results of animal and in vitro studies, ReishiMax has been demonstrated to
-stimulate the formation of antibodies
-stimulate the ability of proliferation of immune cells and
-modulate the function of T cells.
These studies show that ReishiMax has the ability to enhance and help maintain a healthy immune system.
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

19. ReishiMax enhances cell-mediated immune functions*
Placebo
0.585
1.170
ReishiMax GLP
2.925
(g/kg)
Other
Reishi
1000
2000
3000
4000
5000
Interleukin-2 (pg/ml)
p<0.001 by ANOVA
+405%
+822%
+799%
p=0.12
Cell-mediated Immune: Blocking and eliminating infectious agents via immune cells, such as T cells and NK cells
Interleukin-2 (IL-2) is an interleukin, a type of cytokine immune system signaling molecule, which is a leukocytotrophic hormone that is instrumental in the body's natural response to microbial infection and in discriminating between foreign (non-self) and self. IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes, the cells that are responsible for immunity.
By Medical Institute at National Taiwan University
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

20. Higher Amount of Actives
min 10 20 30 40 50
mAU
100
200
Other Reishi product GA
Ganoderol B
Ganoderol acid DM-std
ReishiMax
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

21. Higher Solubility 90% 71% 51% 0% 10% 20% 30% 40% 50% 60% 70% 80%
ReishiMax
Reishi A
Reishi B
By Pharmanex Research Center at Shanghai Medical University
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

22. Competitive Advantage
6S process
Best natural Red Reishi species
Organic cultivation
Cracked spores
Proprietary manufacturing technology
Highest level of actives on the market
Scientifically proven
Pharmanex ReishiMax has a strong competitive advantage over other Reishi products.
-Pharmanex ReishiMax contains the highest levels of actives on the market for a Reishi product
-the Reishi mushroom is organically grown. The natural log cultivation method grows reishi without the use of heavy metals or unwanted debris
-Pharmanex ReishiMax uses the most scientifically studied strain of Reishi. Red Reishi
-Only ReishiMax incorporates the “cracked spore” technology
-As with all of our Pharmanex products, ReishiMax is produced under our strict 6S process to ensure quality ingredients, qualified manufacturers, and certified independent laboratory verification
-A health food license was granted for ReishiMax by the Taiwan DOH in April It is only one of 23 licenses that have been issued for health foods by the DOH!
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

23. Recommended Usage Take twice daily with meals:
1 capsule each time for health maintenance
2 capsules each time for immune modulation
Safe and well tolerated at the recommended dosage
ReishiMax is safe and well tolerated at the recommended dosage. ReishiMax is recommended twice daily with meals. For normal health maintenance, one capsule should be taken twice daily. For immune modulation, two casules of ReishiMax should be taken twice daily with food.
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

24. Taken together, ReishiMax and Tegreen 97 provide a comprehensive cellular health maintenance program*
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

25. THANK YOU