1. Self & Non-self

2. Recognizing Self MHC – Major Histocompatability Complex
Antigens your own cells produce and have attached to their surfaces
Class I MHCs – found on all body cells
Class II MHCs – found on macrophages and B cells

3. Common Transplants Organs Heart Lungs Liver Kidneys Pancreas Tissues
Cornea
Blood
Blood Vessels
Bone Marrow
Cartilage and Ligaments
Skin

4. Transplants Don’t just have to match blood types, but also MHCs
Tissue rejection – the recipient’s immune system attacks the donated tissue
Immunosuppressant Drugs – decrease MHC response

5. Autoimmune Diseases
Results from either a lack of suppressor T cells or an inability to recognize self

6. Common Autoimmune Diseases
Type I Diabetes – immune system attacks beta cells of the pancreas
Rheumatoid arthritis – immune system attacks the cartilage of the joints

7. Multiple Sclerosis – immune system attacks myelin around neurons
Cannot conduct nerve impulses
Starts with numbness, tingling, progresses to muscle weakness and eventually paralysis
Can also cause vision problems, emotional and cognitive difficulties, dizziness, and pain