1. 11/7/2018
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2. Treatment of Osteoporosis
One injection of
Zoledronic Acid
a year ?
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3. Volume 346: Feb 28, 2002 Number 9
Intravenous Zoledronic Acid in Postmenopausal Women with Low Bone Mineral Density
Ian R. Reid et al
Zoledronic acid infusions given at intervals of up to one year produce effects on bone turnover and bone density as great as those achieved with daily oral dosing with bisphosphonates with proven efficacy against fractures, suggesting that an annual infusion of zoledronic acid might be an effective treatment for postmenopausal osteoporosis.
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4. … a therapeutic vaccine against the OPG-L
Oct ASBMR
… a therapeutic vaccine against the OPG-L
… could prevent / treat diseases associated with increased osteoclast activity and bone loss
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5. Cholesterol drugs may protect bones
About half of women over 50 have a fracture because of osteoporosis sometime during their lives.
Cholesterol drugs may protect bones
Statins could offer women an alternative to hormone replacement therapy
June 22 —  Drugs commonly used to lower cholesterol could also help prevent bone fractures and osteoporosis in older women, offering an alternative to hormone replacement therapy, researchers said.
MSNBC NEWS SERVICES
11/7/2018
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6. Effects of Simvastatin on murine calvaria in vitro
Statins Stimulate Bone Formation
Effects of Simvastatin on murine calvaria in vitro
Mundy G. et al Stimulation of bone formation in vitro and in rodents by statins Science. 286(5446):1946-9, 1999 Dec 3.
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7. How these two worlds came together
Bisphosphonates
and Statins
How these two worlds came together
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8. Bisphosphonates and Statins Mevalonate pathway
use a common pathway:
the
Mevalonate pathway
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9. The Mevalonate pathway
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