1. Principles of Medical Microbiology
Principles of Infectious Disease:
The Host-Parasite Relationship
Colonization, Normal Microbiota & Symbiotic Relationships
Pathogenicity and Virulence
Mechanisms of Pathogenicity
Epidemiology
Mechanisms of Immunity
Beneficial
Harmful
Manipulated
Antimicrobial Chemotherapy

2. Principles of Infectious Disease
The Host-Parasite Relationship
Colonization and Normal Microbiota
Permanent residents, transients and opportunists
Symbiotic Relationships
Mutualism, Commensalism, Parasitism
Pathogenicity and Virulence
Evolution of parasitism
Attenuation of virulence
The Infectious Process:
1) Exposure: Oral, respiratory, parenteral, etc
2) Attachment: Pili, capsules, proteins, etc
3) Colonization: Metabolism, replication, avoid clearance
4) Tissue Damage: Toxins, invasiveness, immune response

3. Principles of Infectious Disease
The Host-Parasite Relationship
Colonization and Normal Microbiota
Permanent residents, transients and opportunists
Symbiotic Relationships
Mutualism, Commensalism, Parasitism
Pathogenicity and Virulence
Evolution of parasitism
Attenuation of virulence
The Infectious Process:
1) Exposure: Oral, respiratory, parenteral, etc
2) Attachment: Pili, capsules, proteins, etc
3) Colonization: Metabolism, replication, avoid clearance
4) Tissue Damage: Toxins, invasiveness, immune response

4. Colonization

5. Normal Microbiota

6. Principles of Infectious Disease
The Host-Parasite Relationship
Colonization and Normal Microbiota
Permanent residents, transients and opportunists
Symbiotic Relationships
Mutualism, Commensalism, Parasitism
Pathogenicity and Virulence
-Evolution of parasitism
-Attenuation of virulence
The Infectious Process:
1) Exposure: Oral, respiratory, parenteral, etc
2) Attachment: Pili, capsules, proteins, etc
3) Colonization: Metabolism, replication,
avoidance of immune clearance
4) Tissue Damage: Toxins, invasiveness,
adverse immune response

7. Routes of Exposure

8. Attachment

9. Colonization

10. Avoiding the Immune Response

11. Avoiding the Immune Response

12. Tissue Damage: Invasiveness

13. Tissue Damage: Invasion

14. Tissue Damage: The Action of Exotoxins

18. Infectious vs contagious; Chronological sequence;
Epidemiology
Reservoirs of Agents
Humans, Animals, Inanimate, Nosocomial
Transmission of Agents
Contact, Vectors, Vehicles
Disease Categories
Infectious vs contagious; Chronological sequence;
Geographical distribution; Incidence rates;
Extent of involvement; Agents; Clinical nature

19. Nosocomial Infections

20. Transmission: How the Microorganisms Spread

21. Portals of Entry: How the agents enter the body

22. Incidence

23. Emerging Diseases

25. The Immune System Functions of the Immune System
Types of Immune Responses
Organization of the Immune System
Innate Defense Mechanisms
Acquired Defense Mechanisms
Applied Immunology
A macrophage

26. The Immune System Functions of the Immune System
Defense – Recognition of…
Homeostasis – Recognition of…
Surveillance – Recognition of…
Types of Immune Responses
Humoral – Transferred by…
Cellular – Transferred by…
Innate – First and second line defenses
Acquired – “Antigen driven” third line defenses
Recognition, Specificity, Memory
Organization of the Immune System
Innate Defense Mechanisms
Acquired Defense Mechanisms
Applied Immunology

27. Epithelial Barriers

28. Chemical Barriers

29. The Immune System Functions of the Immune System
Types of Immune Responses
Organization of the Immune System
Cells:
Phagocytes: Neutrophils, macrophages, APC’s
Antigen responsive cells: B and T cells
Tissues:
Primary: Bone marrow, thymus
Secondary: Lymph nodes, spleen, diffuse lymphoid tissue
Molecules:
Enzymes, interferons, complement, interleukins, antibody
Innate Defense Mechanisms
Acquired Defense Mechanisms
Applied Immunology

30. Hematopoiesis

32. Tissues

34. The Immune System Innate Defense Mechanisms Phagocytosis Inflammation
Functions of the Immune System
Types of Immune Responses
Organization of the Immune System
Innate Defense Mechanisms
Phagocytosis
Inflammation
Interferon
Complement
Acquired Defense Mechanisms
Applied Immunology

35. Distribution of Phagocytic Cells

36. Phagocytosis

37. Inflammation

39. Interferon

40. C’

41. The Immune System Acquired Defense Mechanisms
Functions of the Immune System
Types of Immune Responses
Organization of the Immune System
Innate Defense Mechanisms
Acquired Defense Mechanisms
-Humoral vs cellular specific immunity
-The nature of antigens
-The nature of antibodies
-The functions of antibodies
-Clonal selection
-Humoral (antibody) immune responses
-Cellular immune responses
-Natural killer cells
Applied Immunology

43. Antigens

44. Antibodies

46. Functions of Antibodies

47. Passive Transfer of Antibody

48. Clonal Selection

49. Antibody Production

50. Immunity: -APC’s -Ag Processing -Il-1 Production -Ag Presentation -Th Activation -Il-2 Production -Th Development -Th1 and CMI -Th2 and Antibody -Tc Developement -Tc Killing

51. The Immune System Applied Immunology -Methods of acquiring immunity
Functions of the Immune System
Types of Immune Responses
Organization of the Immune System
Innate Defense Mechanisms
Acquired Defense Mechanisms
Applied Immunology
-Methods of acquiring immunity
-Vaccination
-Immunological-based testing:
ELISA assays
-Clinical immunology

52. Figure 17.1

58. Antimicrobial Chemotherapy
History
Ancient, Ehrlich, Domagck
Terminology
Antibiotics, Synthetic antibiotics, Semi-synthetic antibiotics
Properties of Antibiotics
Selective toxicity, Therapeutic index, Spectrum of activity
Adverse Reactions
Toxicity, Allergy, Disrupt normal microbiota, Resistance
The Ideal Antibiotic
Mechanism of Action
Bacteria, Viruses, Fungi, Protozoa, Helminths