1. Superbisor: Yong Huang
Exploration of Earth-Abundant Transition Metals (Fe, Co,
Ni) as Catalysts in Unreactive Chemical Bond Activations
Bo Su, Zhi-Chao Cao, and Zhang-Jie Shi
Reporter: Li Li
Superbisor: Yong Huang
Acc. Chem. Res. 2015, 48, 886

2. Concept

3. Inert chemical bond activation logic

4. Table Fe catalysis Co catalysis Ni catalysis
Fe-catalyzed C-O activation
Co catalysis
Co-catalyzed C-O activation
Ni catalysis
Ni-catalyzed eheric C-O activation
Ni-catalyzed esteric C-O activation
Ni-catalyzed C-O activation of aryl/alkenyl carbamates.
Ni-Catalyzed C-O bond activation of phenolates
Ni-Catalyzed C-O activation of benzylic alcohols

5. Fe catalysis Fe-catalyzed C-O activation
J. Am. Chem. Soc. 2009,131,

6. Fe catalysis Fe-catalyzed C-O activation
Chem. Commun. 2013, 49,

7. Fe catalysis

8. Co catalysis C-O activation J. Chem. Soc. D ,1970, 847
Eur. J.Org. Chem. 2005, 2005, 989
J. Am. Chem. Soc. 2012, 134,14638

9. Ni catalysis C-O activation Chem. Commun. 2008, 1437
J. Am. Chem. Soc. 2008, 130, 3268

10. Ni catalysis
Rational Design of Selective C-O Activation of Carboxylate
Chem. Lett. 1976, 1091

11. Ni catalysis Selective C−O Activation of Aryl Carboxylates
J. Am. Chem. Soc. 2008, 130, 14468
Chem.Eur. J. 2010, 16, 5844
Angew. Chem., Int. Ed. 2008, 47, 10124

12. Ni catalysis
Tentative Mechanism of the Ni-Catalyzed Selective C-O Activation of Aryl Carboxylates

13. Ni catalysis sp3 C-O Activation of α-Pivaloxyl Ketones
Chem. Commun. 2011, 47, 7224

14. Ni catalysis
Proposed Mechanism of the Ni-Catalyzed sp3 C-O Activation of α-Pivaloxyl Ketones

15. Ni catalysis Selective sp3 C-O Activation of Aryl/Alkenyl Carbamates
Org. Lett. 2010, 12, 884

16. Ni catalysis C-O Activation of Magnesium Naphtholates
Angew. Chem. Int.Ed. 2010, 49, 4566

17. Ni catalysis
Rational Design of the New Mutual Activation Concept

18. Ni catalysis C-O Activation of Sodium Naphtholates
Angew.Chem. Int. Ed. 2011, 50, 7097

19. Ni catalysis
Possible Role of Et3B in the Mutual Activation.

20. Ni catalysis sp3 C-O Bond Activation of Benzylic Alcohols
J. Am. Chem. Soc. 2012, 134,14638

21. Summary Fe-, Co-, and Ni-catalyzed C-O acivation
Unveiling the relationship between their structures and their
reactivity are highly needed
Earth abundant transition-metal catalysis VS late transition-metal
Aliphatic C-H transformations
Designing new ligand for different condition

22. A H K N T S