1. 577 marketing authorisations granted (356 active ingredients) by EU centralized procedure, 1995-2009
522 marketing authorisations granted (339 active ingredients) selected for the analysis
55 marketing authorisations withdrawn, suspended and/or not renewed (45 active ingredients) excluded from the analysis
2 marketing authorisations granted to medicinal products with no specific indication (1 active ingredient) excluded
520 marketing authorisations granted (338 active ingredients) finally included in the analysis with disease burden measures