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Supplemental Figure 1. Figure legend. Synthesis of 5-Amino-2-hydroxy-benzoic acid 4-(5-thioxo-5H-[1,2]dithiol-3-yl)-phenyl ester (5-ASA-ADT, 4). Reaction.

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Presentation on theme: "Supplemental Figure 1. Figure legend. Synthesis of 5-Amino-2-hydroxy-benzoic acid 4-(5-thioxo-5H-[1,2]dithiol-3-yl)-phenyl ester (5-ASA-ADT, 4). Reaction."— Presentation transcript:

1 Supplemental Figure 1. Figure legend. Synthesis of 5-Amino-2-hydroxy-benzoic acid 4-(5-thioxo-5H-[1,2]dithiol-3-yl)-phenyl ester (5-ASA-ADT, 4). Reaction conditions (yield): a, sulfur, DMF, reflux (13%); b, di-tert-butyl dicarbonate, triethylamine, dioxane/water (2/1), 0°C (80%); c, ADT-OH (2), DCC/HOBt, 0°C for 3h and then rt for 72 h; d, 40% TFA in DCM, rt (40% for two steps). Abbreviations: DMF, dimethylformamide; DCC, N,N'-dicyclohexylcarbodiimide; HOBt, 1-hydroxybenzotriazole; TFA, trifluoroacetic acid; DCM, dichloromethane.

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