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Justin C. Williams, Paul J. Campagnola  Neuron 

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Presentation on theme: "Justin C. Williams, Paul J. Campagnola  Neuron "— Presentation transcript:

1 Wearable Second Harmonic Generation Imaging: The Sarcomeric Bridge to the Clinic 
Justin C. Williams, Paul J. Campagnola  Neuron  Volume 88, Issue 6, Pages (December 2015) DOI: /j.neuron Copyright © 2015 Elsevier Inc. Terms and Conditions

2 Figure 1 Description and Demonstration of Wearable SHG Microscope
(A) An alert subject wears the microscope during imaging of the tibialis anterior muscle. Two optical fibers that deliver laser illumination (blue sheath) and collect SHG signals (red sheath) provide flexible optical coupling to a mobile cart. (Inset) Light source, photodetector, and computer reside on the cart. (B) Cross-section of the CAD diagram of the microscope, showing the housing, optical components, and electrical line used to excite motor neurons via the microendoscope. (Inset) Magnified view of the probe tip and the muscle fiber orientation during imaging. (C and D) SHG line-scans of the biceps brachii of the relaxed, affected, and unaffected limb, respectively, of a poststroke subject. Scale bars are 10 μm (vertical) and 100 ms (horizontal). Adapted from Sanchez et al. (2015). Neuron  , DOI: ( /j.neuron ) Copyright © 2015 Elsevier Inc. Terms and Conditions

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