1. Pseudomonas Infection in Cystic Fibrosis

2. Development of Chronic Pseudomonas Infection in CF Airways

3. Development of Chronic Airways Infection

4. Development of Chronic Pseudomonas Infection in CF Airways

5. Respiratory Infection in CF Patients Prevalence of Respiratory Microorganisms by Age in 2013

6. Opportunities for Inhaled Antibiotics in CF

7. Inhaled Antibiotics Standard of Care in CF Airway Infection

8. Aerosolized Antibiotics in CF

9. Growing Knowledge of Tobramycin Pharmacokinetics in CF

10. In Vitro Sputum Inhibition of IV Tobramycin Activity

11. Development of Inhaled Tobramycin

12. Tobramycin Solution for Inhalation 24 Weeks of Intermittent Therapy -- Phase 3 Completed 1996

13. Inhaled Antibiotics Targeting Pseudomonas

14. Use of Inhaled Antibiotics Clinical Questions

15. Guidelines for Inhaled Antibiotics in CF

16. Is Intermittent Therapy the Right Regimen?

17. Inhaled Antibiotic Use in Clinical Practice

18. Options?

19. Continuous Alternating Therapy (CAT)

20. CAT Study Design

21. Primary Endpoint Protocol-Defined Exacerbation

22. Secondary Endpoints Protocol-Defined Exacerbation and Hospitalization

23. Conclusions

24. Abbreviations

25. Abbreviations (cont)