1. The DANAMI-2 Trial Danish Trial in Acute Myocardial Infarction-2
Presented at the American College of Cardiology
51st Annual Scientific Session
Atlanta, GA
Dr. Henning Rud Andersen
for the DANAMI-2 investigators

2. DANAMI-2: Study Design Primary PCI Lytic therapy Primary PCI
High-risk ST elevation MI patients (>4 mm elevation), Sx < 12 hrs
5 PCI centers (n=443) and 22 referring hospitals (n=1,129), transfer in < 3 hrs
Lytic therapy
Front-loaded tPA 100 mg
(n=782)
Primary PCI
with transfer
(n=567)
Primary PCI
without transfer
(n=223)
Death / MI / Stroke at 30 Days
Stopped early by safety and efficacy committee

3. DANAMI-2: Centers

4. DANAMI-2: Primary Results
Combined
Transfer Sites
Non-Transfer Sites
P=0.0003
P=0.002
P=0.048
RRR 40%
RRR 45%
RRR 45%
Death / MI / Stroke (%)
Lytic
Primary PCI
Lytic
Primary PCI
Lytic
Primary PCI

5. DANAMI-2: Results Stroke Death Recurrent MI Lytic Primary PCI Lytic