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CPEG Reseach Activities – An Overview
Guang R. Gao Computer Architecture and Parallel Systems Laboratory Dept. of Electrical and Computer Engineering University of Delaware 9/18/2018 \capsl\bioinfor.ppt
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CPEG Faculty John Elias Guang R. Gao Dave Mills Fouad Kiamilev
Kevin Theobald Peter Warter (Emeritus) 9/18/2018 \capsl\bioinfor.ppt
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Research Areas Traditional Computer Engineering Research Areas:
Computer Networking (Mills) VLSI Design for Optical Comm. (Kiamilev) Computer Systems, Compilers and Software (Gao) Neuromorphic Engineering and User Interfaces (Elias) Computer Architecture and Hardware (Theobald) High-Performance Computing for Biotechnology 9/18/2018 \capsl\bioinfor.ppt
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John Elias: Research Interests
Neuromorphic Engineering Silicon neurons Neurocomputation User Interfaces (collaboration with Prof. Westerman) Gesture based Multi-hand and Multi-finger Unified (touch, voice, force, gesture, etc.) 9/18/2018 \capsl\bioinfor.ppt
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Professors Westerman and Elias: The FingerBoard
Integrates typing, mouse, and gesture input. Touch sensitive surface images multiple fingers and multiple hands. Gesture used to control graphics, text, and apps. Commercialization underway 9/18/2018 \capsl\bioinfor.ppt
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FingerBoard Product Concept
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FingerBoard Product Concept
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Kiamilev: Active Projects
Honeywell (DARPA VLSI Photonics) Lockheed (DARPA STAB) Mayo (DARPA VLSI Photonics) GMU (DARPA P-WASSP) OE Consortium East Coast (DARPA) GORE Photonics (IR&D) SUN Microsystems (IR&D) Xilinx (Teaching equipment grant) 9/18/2018 \capsl\bioinfor.ppt
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CVORG: CMOS for VLSI Opto-Electronics Group
Prof. Fouad Kiamilev, Jeremy Ekman, Premanand Chandramani, Ping Gui, Xiaoqing Wang, Muhammad Fikri, Amitava Bhaduri 12Gbit/sec PCI NIC for workstation clusters. Demonstrated communication between 2 dell workstations in Q4/2000. Funding Source: Darpa MTO Partners: Honeywell, Sun, Intel 10Gbit/sec SiGe circuits and advanced communication and power-saving protocols for parallel optical links. Funding Source: Darpa MTO, ITO Partners: Raytheon, Mayo Clinic, BAE 32-port 12Gbit/sec/port router using MCM and free-space optical interconnect. Funding: Darpa Partners: Honeywell 4 mm 9/18/2018 \capsl\bioinfor.ppt
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Mills: Research Projects
Autonomous Configuration and Authentication in Very Large Networks Simulation of Very Large Networks CAKRD/DARTnet Collaboration Network Time Synchronization Project Precision Time Synchronization Fault-Tolerance Time Synchronization 9/18/2018 \capsl\bioinfor.ppt
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Kevin B. Theobald Models for parallel computation based on two-level multithreading Evolutionary path to effective MPP for irregular applications on COTS processors Hardware prototype SU being developed for cluster of 16 PCs EARTH (Efficient Architecture for Running Threads) divides processing between a COTS "Execution Unit" and a custom "Synchronization Unit" 9/18/2018 \capsl\bioinfor.ppt
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Gao: Research Projects
Execution model for the HTMT Petaflop Architectures High-Performance Compiler Infrastructure Power-Aware Software Optimization for Embedded Architectures Architecture/Compiler Design Issues for Single-Chip Multiprocessors High-Performance Visualization 9/18/2018 \capsl\bioinfor.ppt
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Core Intellectual Capacity -- An Overview
Bio/Medical applications Core Technology/Asset Discovery Informatics EARTH Technology Programming tools Runtime software Hardware Compiler Technology Retargeting Tools HPC System and Applications Embedded System and Applications 9/18/2018 \capsl\bioinfor.ppt
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Computation Biology/Bioinformatics Overview
focus: Parallelization of certain key information mining and discovery algorithm High-performance modeling and simulation tools - Virual reality visualization tools Data collection & Organization Information Mining & Discovery Database Modeling Simulation/ Emulator Result presentation/visualization 9/18/2018 \capsl\bioinfor.ppt
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CAPSL Bioinformatics Portal Service Model
User-1 User-2 User-n . . . CAPSL BIOINFOR Web Interface Public Resources CAPSL HPC Bioinformatic toolbox CAPSL internal Database High-speed Network External Private Resources High-Performance Parallel Computing Servers EARTH Technology 9/18/2018 \capsl\bioinfor.ppt
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A Sketch of CAPSL Bioinformatic Tool Development
High-Performance Bioinformatic Toolset/Testbed Modeling/Simulation/Emulation Multiple Sequence Alignment & Visualization Expression Analysis & Visualization Pathway Analysis & Visualization Sequence Database & Tools Array Database & tools Pathway Database & tools A Sketch of CAPSL Bioinformatic Tool Development 9/18/2018 \capsl\bioinfor.ppt
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Pilot Research Projects
Discovery Informatics sequence similarity search structure homology search (MSA, SNP, etc.) pattern discovery for arrays Predictive Modeling and Simulation biological pathway modeling and simulation protein structure prediction Visulaization 9/18/2018 \capsl\bioinfor.ppt
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BioMEX Model and Testbed
Transcript expression Profiles across perturbation series Arterial Baroreceptors Cardiac Ganglion Heart and Peripheral Vasculature mRNA in identified cell type (a) Intercellular Level Principal Neuron and other homeostatic control neurons NTS Inter NA/DMN Cardiorespiratory control circuit (b) Signaling Pathway Ca2+ MICRO messenger p3 Threaded programs p1 p2 receptor p4 K+ BIOMEX Platform Modeled by ODE dr dt dp (c) Gene Network BIOMEX Engine Threaded Algorithm for ODE/PDE implementation DNA = f(p) - Vr mRNA Protein High-speed net DNA mRNA Protein = Lr - Up Bioinformatics Server Visualization Server BioMEX Model and Testbed INFO 9/18/2018 \capsl\bioinfor.ppt
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New Bioinformatics Courses
ELEG : Discovery Informatics : fall 2000 (with Prof. Javier Garcia-Frias ) ELEG : Discovery Informatics II: Spring 2001 (With Prof. Javier Garcia-Frias) ECE/DBI Joint Distinguished Seminar: IBM Blue Gene Project (M. Snir) Other ECE/CAPSL seminars (NCBI, Fox Chase, etc.) 9/18/2018 \capsl\bioinfor.ppt
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Industry Connections DuPont AstroZenica Others 9/18/2018
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Summary Multi-discipline team for novel algorithms, modeling and visualization methods In-house high-performance computing capability for joint research with collaborators New education activities tighted into rigorous research programs 9/18/2018 \capsl\bioinfor.ppt
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